Neuropeptides
1986
K Kmieciak-Kołada, J Kowalski
The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus with hypothalamus the LENK level fell after the administration of LSD,...
Journal of Neurochemistry
1986
J J Grome, A M Harper
40 citations
Substances with varying structural components have been shown to have 5-hydroxytryptamine (5-HT)-like properties in the CNS. In this study, putative 5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine moieties--quipazine (Quip) and 6-chloro-2-(1-piperazinyl)pyrazine (6-CPP) were administered to rats....
Journal of Religion and Health
December 1, 1985
C M Bache
18 citations
This essay offers a reassessment of Teresa's severe seizures which were such a characteristic feature of her mysticism. The diagnosis of hysteria is no longer viable, at the very least given its abandonment by clinicians. An alternative analysis is developed by phenomenologically comparing Teresa's seizures to parallel experiences of subjects in LSD-assisted psychotherapy. Using Stanislav...
Pharmacology, Biochemistry, and Behavior
May 1985
David J. Mokler, K W Stoudt, Richard H. Rech
Indolealkylamine and phenethylamine hallucinogens disrupted responding maintained under a fixed-ratio 40 (FR-40) schedule of reinforcement. LSD, DMT, mescaline and DOM produced dose-dependent decreases in number of reinforcers and increases in 10-sec periods of non-responding (pause-intervals). The 5HT agonist quipazine, as well as the LSD congener lisuride, altered response patterns in a...
Journal of Drug Issues
April 1, 1985
William H. Mcglothlin
2 citations
This paper presents an argument for research into the means of altering individual attitudes, values, and communication abilities in the direction of increased social empathy, which, in turn, would produce a more favorable environment for resolving differences and facilitate peaceful negotiations between individuals and nations. It is proposed that prior research with the drug, d-lysergic acid...
Psychopharmacology
1985
E B Nielsen, J B Appel
Rats were trained to press a lever under a variable-interval (VI) schedule of water reinforcement. After stable responding had developed, a 4.5-KHz tone (CS) was conditioned classically to a 2.5-mA electric shock (US) in groups of animals which had been given various psychoactive drugs or saline. Twenty-four hours later, a stimulus generalization test was conducted in the absence of drug;...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
1985
L M Adams, Mark A. Geyer
A previously proposed animal model of lysergic acid diethylamide's (LSD) effects in humans was tested for its applicability to other hallucinogens, 2,5-dimethoxy-4-methyl amphetamine (DOM) and N,N-dimethyltryptamine (DMT). Both "free" and "forced" exploration tests in a behavioral pattern monitor were used to determine the effects of these hallucinogens on the normal tendencies of rats to avoid...
Life Sciences
December 17, 1984
Richard A Glennon, M Titeler, J D Mckenney
636 citations
The affinities (Ki values) of twenty two psycho-active agents, including LSD, 5-OMe DMT and a series of phenalkylamine derivatives, for cortical 5-HT1 and 5-HT2 binding sites were compared with two measures of behavioral activity. It was found that a significant correlation (r = 0.938) exists between the 5-HT2 binding affinities of these agents and their ED50 values as determined in tests of...
Pharmacology, Biochemistry, and Behavior
February 1984
Jerrold C Winter
A group of six rats was trained to discriminate the effects of para-methoxyamphetamine (PMA; 3 mg/kg, 15 min pretreatment time) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Stimulus control was assumed to be present when 80% or more of the first ten responses were appropriate for the treatment condition on each of five consecutive days. PMA...
Experimental eye research
November 1983
M Kemali, N Milici, D Kemali
Pigment screening (PS) occurs in the retina of lower vertebrates and consists of the bidirectional migration (vitreally or sclerally) of melanin granules into processes of the pigment epithelium that extend between photoreceptors, in response to changes in the illumination conditions. We have studied the effect of some neuroactive drugs on the PS of frogs maintained under cyclic lighting...