Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents.
Life Sciences December 17, 1984 Richard A Glennon, M Titeler, J D Mckenney 636 citations
The affinities (Ki values) of twenty two psycho-active agents, including LSD, 5-OMe DMT and a series of phenalkylamine derivatives, for cortical 5-HT1 and 5-HT2 binding sites were compared with two measures of behavioral activity. It was found that a significant correlation (r = 0.938) exists between the 5-HT2 binding affinities of these agents and their ED50 values as determined in tests of...