Involvement of the central serotoninergic system in the changes of leu-enkephalin level in discrete rat brain areas.
K Kmieciak-Kołada, J Kowalski
Neuropeptides 1986 DOI: 10.1016/0143-4179(86)90028-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Rat brain tissue (frontal cortex, thalamus with hypothalamus, striatum) |
| Interventions | LSD mescaline m-CPP citalopram fenfluramine methergoline methiothepin |
| Topics | Serotonin |
| Key findings | Acute LSD decreased and chronic LSD increased leu-enkephalin content in rat frontal cortex, while LSD, mescaline, citalopram, and fenfluramine lowered LENK in the thalamus with hypothalamus and, except fenfluramine, raised it in the striatum. Methergoline and methiothepin prevented these LSD effects. The authors conclude that the serotoninergic system may modulate the LENK pathway. |
Abstract
The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus with hypothalamus the LENK level fell after the administration of LSD, mescaline, citalopram and fenfluramine, while in the striatum it increased significantly, except for fenfluramine treatment. Methergoline and methiothepin prevented the effects of acute and chronic LSD administration. The diminished LENK level was associated with a decrease of 5-HT or 5-HIAA content in the rat brain areas investigated. Therefore, it has been concluded that the serotoninergic system may modulate the LENK pathway.
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| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
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