Mental Health Weekly
May 28, 2021
The use of psychedelics is evolving for the treatment of a variety of mental illnesses, including anxiety, depression, post‐traumatic stress disorder and other related uses, Financial News Media reported May 25. Some psychedelic drugs are extracted from plants or mushrooms, and some are synthetic (human‐made). These drugs are now considered effective for patients with treatment‐resistant...
Expert Review of Clinical Pharmacology
May 26, 2021
Suresh Muthukumaraswamy, Anna Forsyth, Thomas Lumley
312 citations
Introduction: There is increasing interest in the potential for psychedelic drugs such as psilocybin, LSD and ketamine to treat several mental health disorders, with a growing number of randomized controlled trials (RCTs) being conducted to investigate the therapeutic effectiveness of psychedelics.Areas covered: We review previous literature on expectancy effects and blinding in the context of...
Translational Psychiatry
May 20, 2021
Rebeca Dı́ez-alarcia, Carolina Muguruza, Guadalupe Rivero et al.
27 citations
Abstract The status of serotonin 5HT 2A receptors (5HT 2A Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5HT 2A R density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study...
AJN, American Journal of Nursing
May 19, 2021
Diane Szulecki
Figure: This month's cover features a colorized magnetic resonance imaging scan of a human brain—a nod to Penn and colleagues' article “Psychedelic-Assisted Therapy,” which presents an overview of a growing field that nurses are positioned to be part of. Photo by Daisy Daisy / Shutterstock.This month's cover features a colorized magnetic resonance imaging scan of a human brain—a nod to Penn and...
World Psychiatry
May 18, 2021
Wayne Hall
17 citations
A psychedelic drug is one that “produces thought, mood and perceptual changes otherwise rarely experienced except in dreams, contemplative and religious exaltation, flashes of vivid involuntary memory, and acute psychosis”1. It does so “without causing physical addiction, craving, major physiological disturbances, delirium, disorientation or amnesia”1. The “classic psychedelics” include...
Suchttherapie
May 1, 2021
[ Abb. 1 ] zeigt die Strukturformel, die Anwendungsarten und die handelsüblichen Formen von DMT (Dimethyltryptamin). Substanz Tryptaminhaltige Pflanzen wurden über mehrere 1000 Jahre von südamerikanischen Ureinwohnern bei religiösen Ritualen und zu medizinischen Zwecken eingenommen. Ziel dabei war die Provokation visionärer Erlebnisse als Kontaktaufnahme mit einer jenseitigen Welt, z. B. um die...
ACS Chemical Neuroscience
April 28, 2021
Eline Pottie, Olga V. Kupriyanova, Vadim A Shevyrin et al.
Serotonergic psychedelics, substances exerting their pharmacological action through activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a substantial fraction of the over 1000 reported New Psychoactive Substances (NPS) so far. Within this category, N-benzyl derived phenethylamines, such as NBOMes and NBFs, have shown to be of particular relevance. As these substances...
Molecules
April 22, 2021
Paul Cumming, Milan Scheidegger, Dario Dornbierer et al.
45 citations
Hallucinogens are a loosely defined group of compounds including LSD, N,N-dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-methamphetamine (DOM), which can evoke intense visual and emotional experiences. We are witnessing a renaissance of research interest in hallucinogens, driven by increasing awareness of their psychotherapeutic potential. As such, we now present a...
Journal of Clinical Psychopharmacology
April 13, 2021
Juliana Mendes Rocha, Giordano Novak Rossi, Flávia de Lima Osório et al.
46 citations
Abstract Background The recognition of emotions in facial expressions (REFE) is a core aspect of social cognition. Previous studies with the serotonergic hallucinogens lysergic acid diethylamide and psilocybin showed that these drugs reduced the recognition of negative (fear) faces in healthy volunteers. This trial assessed the acute and prolonged effects of a single dose of ayahuasca on the...
European Psychiatry
April 1, 2021
M. Trigo
Introduction Depression is one of the most prevalent mental illnesses, leading to important personal distress and economic consequences. Treatment is long, often involving psychotherapy and pharmacological treatment, and relapses are frequent. Used mostly for treatment of mood disorders and alcohol dependence, drugs such as lysergic acid diethylamide (LSD) were studied in the 1950’s and showed...