Carolina Muguruza

2 papers in the library · 111 citations · publishing 2020-2021

Papers

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Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile

Translational Psychiatry May 20, 2021 Rebeca Dı́ez-alarcia, Carolina Muguruza, Guadalupe Rivero et al. 27 citations

Abstract The status of serotonin 5HT 2A receptors (5HT 2A Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5HT 2A R density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study...

DOI: 10.1038/s41398-021-01430-7 Full text Serotonin Inverse agonist Antipsychotic Schizophrenia object-oriented programming +8

Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure

Neuropsychopharmacology January 26, 2020 Adán de Salas-Quiroga, Daniel García-Rincón, Daniel Gómez-Domínguez et al. 84 citations

Abstract Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC affects the development of pyramidal neurons and GABAergic interneurons via cannabinoid CB1 receptors (CB1R). However, the particular contribution of these two neuronal...

DOI: 10.1038/s41386-020-0621-3 Full text