Rebeca Dı́ez-alarcia

2 papers in the library · 105 citations · publishing 2018-2021

Papers

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Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile

Translational Psychiatry May 20, 2021 Rebeca Dı́ez-alarcia, Carolina Muguruza, Guadalupe Rivero et al. 27 citations

Abstract The status of serotonin 5HT 2A receptors (5HT 2A Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5HT 2A R density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study...

DOI: 10.1038/s41398-021-01430-7 Full text Serotonin Inverse agonist Antipsychotic Schizophrenia object-oriented programming +8

Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway

Neuropsychopharmacology April 27, 2018 Inés Ibarra‐Lecue, Irene Mollinedo-Gajate, J. Javier Meana et al. 78 citations

Long-term use of potent cannabis during adolescence increases the risk of developing schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several findings suggest that the functional selectivity of serotonin 2A receptor (5-HT2AR) through inhibitory G-proteins is involved in the molecular mechanisms responsible for psychotic symptoms. Moreover, this receptor is...

DOI: 10.1038/s41386-018-0076-y Full text