Tiletamine, a veterinary anesthetic related to ketamine, produces dose-dependent sedative effects in adult zebrafish. Immersion in 1 mg/L caused only reduced top entries in a novel tank test, while 5 and 10 mg/L caused robust sedation and skin darkening. Brain samples confirmed tiletamine presence only at the two higher doses. The results demonstrate potent neurotropic effects of tiletamine in zebrafish and support the use of fish-based aquatic screens for studying NMDA receptor antagonists.
A new compound in the NBOMe series of hallucinogenic phenethylamines, 2,4,6-TMPEA-NBOMe, was identified in the illicit drug market using multiple analytical techniques including GC/MS, high-resolution mass spectrometry, and NMR spectroscopy. The study describes the compound's fragmentation patterns under electron ionization, noting that a McLafferty rearrangement occurs despite an empirical rule that would predict otherwise, and that electron-donating methoxy groups favor this rearrangement. N-methyl and N-acyl derivatives did not show the rearrangement, while N-acyl derivatives exhibited it with charge retention on an alternative fragment. Analytical characteristics for detecting the compound in criminal seizures are provided.