Psychedelics are psychoactive substances that are known to alter perception, alter mood, and affect numerous cognitive processes. Throughout history, psychedelics were utilized in ceremonies and rituals, and in the 20th century, their utilization in psychiatry began. In the 1960s they became a banned substance and are only recently being revisited for their benefits. The main forms of...
Importance A clear and comprehensive understanding of risks associated with psychedelic-assisted therapy is necessary as investigators extend its application to new populations and indications. Objective To assess adverse events (AEs) associated with classic psychedelics, particularly serious AEs (SAEs) and nonserious AEs (NSAEs) requiring medical or psychiatric evaluation. Data Sources The...
One of the main causes of misery and incapacity is chronic pain, which is frequently linked to psychological issues. Psychedelic substances are drugs that can exert a psychological effect on patients. Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin, exert their action mainly via activation of the serotonin-2A (5-HT2A).1 In a trial to understand the actual mode of action...
With the discovery of the antidepressive effects of ketamine and the increasing withdrawal of the pharmaceutical industry from the development of new psychotropic drugs, the psychiatric research into the clinical application of hallucinogens in psychiatry has literally blossomed in the last two decades. Promising results for various treatment approaches with psychedelic agents, such lysergic...
LSD-assisted therapy may reduce anxiety, but a recent study saw adverse effects like paranoia requiring antipsychotics and overnight monitoring in one participant. Psilocybin-assisted therapy showed promise for alcohol use disorder compared to placebo, but the study also involved extensive psychotherapy which likely contributed to improvements. Psychological risks exist and must be considered...
Accurate and generalizable classification of brain states is essential for understanding their neural underpinnings and improving clinical diagnostics. Traditionally, functional connectivity patterns and graph-theoretic metrics have been utilized. However, cortical gradient features, which reflect global brain organization, offer a complementary approach. We hypothesized that a machine learning...
Psychedelics have been used therapeutically for thousands of years by various cultures, and the term "novel therapeutic agent" should not describe them. The classic psychedelics are mainly tryptamines (e.g., psilocybin, DMT, LSD) and phenethylamines (e.g., MDMA, mescaline, 2C-B), with tryptamines being more studied currently. While most psychedelics are medically safe, some like ibogaine and...
Psychedelics generally elicit a profound change in consciousness, often with ego dissolution, mystical experiences, and enriched sensory perception, but are medically safe for most. Tachyphylaxis occurs after repeated psychedelic administration, preventing biological dependence. MDMA may have some abuse potential and less tachyphylaxis compared to LSD/psilocybin. Psychedelics have 5-HT2B...
Clinical Case ReportsAugust 30, 2024Seragnoli Federico, Martignoni Geo, Martignoni Entela et al.3 citations
Key Clinical Message This case study describes the feasibility and safety of psychedelic‐assisted therapy (PAT) as a home‐based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well. This case supports the feasibility and safety of PAT for patients with life‐threatening conditions in a home setting. Abstract...
There is a psychedelic renaissance with key drugs that alter perception and mood being given breakthrough therapy status as potential treatments for common mental health conditions. If approved, these drugs may be used alongside psychedelic-assisted therapy (PAT), a therapeutic process supporting learning from taking psychedelics. Nearly 100 companies, mainly across America, Canada, Europe, and...