ACS Omega
September 24, 2024
Ana Y Martínez, Alexis Caballero, Rodrigo Ramírez et al.
Psychedelics are psychoactive substances that produce changes in thoughts and feelings and modifications in perceptions of reality. The most potent psychedelic is also the first semisynthetic hallucinogen (lysergic acid diethylamide). Psychedelics have been investigated for decades because of their potential therapeutic effects in the treatment of neuropsychiatric diseases and also because...
Neuroscience & Biobehavioral Reviews
September 20, 2024
Isabel Werle, Leandro J Bertoglio
17 citations
Threatening events and stressful experiences can lead to maladaptive memories and related behaviors. Existing treatments often fail to address these issues linked to anxiety/stress-related disorders effectively. This review identifies dose ranges associated with specific actions across various psychedelics. We examined psilocybin/psilocin, lysergic acid diethylamide (LSD),...
Journal of Psychiatry and Neuroscience
September 19, 2024
Gabriella Gobbi
7 citations
For 3000 years, psychedelics have been used in religious contexts to enhance spiritual thinking, well-being, and a sense of community. In the last few years, a renaissance in the use of psychedelic drugs for mental disorders has occurred in Western society; consequently, a pressing scientific need to elucidate the intricate mechanisms underlying their actions has arisen. Psychedelics mainly...
Discover Mental Health
September 17, 2024
S K Spoelstra, Robert A Schoevers, S D Venema et al.
8 citations
Despite considerable efforts, tobacco use disorder persists as a significant public health issue. The effectiveness of current smoking cessation therapies is limited, leading to a growing interest in alternative treatment approaches such as psychedelics. The aim of this review is to evaluate the scientific evidence regarding the role of psychedelics in smoking cessation. To identify relevant...
September 13, 2024
Berit Brogaard, Dimitria Electra Gatzia
Abstract This chapter presents findings indicating that psilocybin-induced visual distortions and impaired executive functioning originate in temporary disruptions of attentional mechanisms. It then revisits a predictive processing account of neural processing and argues that this lacks the resources to provide a unified model of the perceptual mechanisms underpinning psychedelic experiences...
September 13, 2024
Chris Letheby, Philip Gerrans
6 citations
Abstract A recent wave of research in psychiatry and neuroscience has re-examined the properties of ‘classic’ psychedelic substances—also known as serotonergic hallucinogens—such as psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT). Evidence to date suggests that psychedelics can be given safely in controlled conditions, at moderate to high doses, and may have...
Cochrane Database of Systematic Reviews
September 11, 2024
Sivan Schipper, Kabir Nigam, Yasmin Schmid et al.
34 citations
Implications for practice Psychedelic-assisted therapy with classical psychedelics (psilocybin, LSD) may be effective for treating anxiety, depression, and possibly existential distress, in people facing a life-threatening disease. Psychedelic-assisted therapy seemed to be well tolerated, with no treatment-emergent serious adverse events reported in the studies included in this review. However,...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
September 7, 2024
Zhen Xuen Brandon Low, Wei Shen Ng, Bey Hing Goh et al.
19 citations
Emerging evidence suggests that classical psychedelics possess immunomodulatory and anti-inflammatory properties; however, these effects are yet to be well-established. This systematic review aims to provide a timely and comprehensive overview of the immunomodulatory effects of classical psychedelics in preclinical studies. A systematic search was conducted on six databases, including CINAHL,...
International Journal of Drug Policy
September 5, 2024
Katie Anderson, Patrick Elf, Amy Isham
6 citations
Despite the surge of interest in psychedelic research in the past decade, largely due to the promise of psychedelics for improving mental health outcomes, there has been comparatively little discussion about the social and environmental consequences of psychedelic drug use. While there is growing evidence to suggest psychedelics could foster a greater connection to the natural world and improve...
UCC Student Medical Journal
September 4, 2024
Megha Kodancha
Psychedelics are psychoactive substances that are known to alter perception, alter mood, and affect numerous cognitive processes. Throughout history, psychedelics were utilized in ceremonies and rituals, and in the 20th century, their utilization in psychiatry began. In the 1960s they became a banned substance and are only recently being revisited for their benefits. The main forms of...