Nervenheilkunde
April 1, 2024
Torsten Passie
1 citation
ZUSAMMENFASSUNG Hanscarl Leuner (1919–1996) gilt aufgrund seines wissenschaftlichen und organisatorischen Engagements als die zentrale Figur der Psycholytischen Therapie in Europa. Die Psycholytische Therapie versucht mithilfe geringer Dosen von Halluzinogenen wie LSD oder Psilocybin Abwehrstrukturen zu lockern und dadurch einen erweiterten Zugang zu unbewussten Konflikten und Seeleninhalten zu...
European Psychiatry
April 1, 2024
K. P. Kuypers
3 citations
Abstract Microdosing psychedelics has garnered considerable attention within both nonprofessional circles and the scientific community in recent years. This method involves taking small, non-hallucinogenic doses of substances like LSD or psilocybin over weeks or months, purportedly to enhance specific behaviors, emotions, or address psychiatric conditions. Exploring these assertions is crucial...
European Psychiatry
April 1, 2024
N. Kabir, B. Anderson, Lisa Bouchet et al.
1 citation
Introduction Growing clinical interest in psychedelic-assisted therapies has led to a second wave of research involving psilocybin, LSD, MDMA and other substances. Data suggests that these compounds have the potential to treat mental health conditions that are especially prevalent in older adults such as depression, anxiety, existential distress and post-traumatic stress disorder. Objectives...
Addiction Biology
April 1, 2024
Stephan Tap
12 citations
Abstract Alcohol use disorder (AUD) remains one of the most prevalent psychiatric disorders worldwide with high economic costs. Current treatment options show modest efficacy and relapse rates are high. Furthermore, there are increases in the treatment gap and few new medications have been approved in the past 20 years. Recently, psychedelic‐assisted therapy with psilocybin and lysergic acid...
Deviant Behavior
March 31, 2024
Blake Beaton, Jurg Gerber
2 citations
The practice of microdosing classic psychedelic drugs (e.g. LSD [lysergic acid diethylamide] and psilocybin) has not only become more commonplace, but has also been shown to have potential in treating various psychological impairments. Much is still unknown about how people who microdose psychedelic drugs learn the processes and protocols for microdosing. To uncover how people learn the various...
The Biochemist
March 28, 2024
Peter J. Duggan, S. Walker
1 citation
A major part of the counterculture that emerged in western societies in the 1960s centred around the use of mind-altering psychedelic drugs such as lysergic acid diethylamide (LSD). Humans had, however, been consuming hallucinogenic substances since prehistoric times and often incorporated them into their religious rituals. Concerns over the effects of potent psychedelics like LSD led to them...
bioRxiv Preprint Server
March 28, 2024
Ophir Netzer, Noa Magal, Yonatan Stern et al.
7 citations
preprint
Traumatic events play a causal role in the etiology of stress-related psychopathologies such as depression and posttraumatic stress disorder (PTSD). Recent research highlighted the therapeutic potential of psychoactive substances in alleviating trauma symptoms among chronic stress-related patients. This study is the first to investigate the impact of psychoactive substances consumed during...
The Biochemist
March 25, 2024
David Nutt
3 citations
Natural psychedelics such as magic mushrooms have a long history of human use of at least 7000 years. Their use underwent a resurgence in the 1950/1960s following the synthesis of LSD as a psychedelic and its use as a medicine with powerful therapeutic benefits. But because non-medical use led to massive cultural changes especially in young people, all psychedelics were banned globally in the...
Journal of Studies on Alcohol and Drugs
March 22, 2024
David Nutt, Celia J. A. Morgan, Sukhpreet Klaire
This Perspectives piece gives a brief overview on the last 70 years of psychedelic research in relation to the treatment of mental illness with a particular focus on addictions. We briefly precis the work in the 19650s/60s that started following the discovery of LSD. Then we overview research developments over the past twenty years driven by emerging neuroscience on these agents, the rise of...
Wiley Interdisciplinary Reviews Forensic Science
March 19, 2024
Julio Ponce
6 citations
Abstract Prodrugs are an important strategy for the development and design of therapeutic drugs. They involve the addition of an easily removable group (such as an ester) to a molecule in order to chemically protect it from metabolism, hydrolysis, or interaction with tissues. In the therapeutic drug market, prodrugs may reduce adverse effects, lead to more accurate tissue delivery, increase...