Progress in Neuro-Psychopharmacology and Biological Psychiatry
1990
P Popoli, A Pezzola, A Scotti de Carolis
1. Clonidine, an alpha-2 adrenergic agonist, induced in rats a synchronization of the electrical activity of the brain (EEG) accompanied by sedation starting from the dose of 0.05 mg/kg, i.p. 2. This drug (0.05 mg/kg, i.p.) was also able to influence both the EEG and behavioural effects elicited by two "dissociative anaesthetics", PCP and KT. 3. At low and moderate doses of these two drugs,...
Journal of Pharmacology and Experimental Therapeutics
September 1, 1989
Wouter Koek, Françis C. Colpaert, James H Woods et al.
Phencyclidine (PCP) inhibits dopamine (DA) uptake and acts as a noncompetitive N-methyl-D-aspartate antagonist by binding to PCP receptors. The PCP analog N-[1-(2-benzo(b)thiophenyl) cyclohexyl]piperidine (BTCP, GK13) is a potent DA uptake inhibitor, but has low affinity for PCP receptors. The behavioral effects of BTCP were compared with those of PCP, ketamine, MK-801 and cocaine. In mice,...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
1989
S Sagratella, A Scotti de Carolis
1. The effects caused by the dissociative anaesthetic drugs (PCP, KT), the sigmaopiates (SKF 10.047, cyclazocine), and the mixed excitatory amino acid antagonist CCP on the electrical activity of the red nucleus in rabbits were compared with PB. 2. Ketamine (10 mg/kg, i.v.) induced the appearance of a pentobarbital-like EEG synusoidal rhythm characterized by an increase in amplitude and a...
Anesthesiology
August 1988
D W Davis, A M Mans, J F Biebuyck et al.
The purpose of this study was to determine the effect of different doses of ketamine on cerebral function at the level of individual brain structures as reflected by glucose use. Rats received either 5 or 30 mg/kg ketamine intravenously as a loading dose, followed by an infusion to maintain a steady-state level of the drug. An additional group received 30 mg/kg as a single injection only, and...
Journal of Pharmacology and Experimental Therapeutics
July 1, 1987
Patrick M. Beardsley, R. Balster
The present studies examined whether dependence could be induced by continuous i.v. infusion of phencyclidine (PCP) in rats as demonstrated by disruptions of operant behavior during withdrawal. Rats were trained to lever press for their daily food rations under fixed-ratio 30 schedules of reinforcement during four, daily, 0.5-hr sessions. In the first study, withdrawal from 10 days of PCP...
Indian Journal of Psychiatry
October 1, 1985
Golechha Gr, Rao Av, Ruggu Rk
Ketamine is a rapid acting parentrally administered non barbiturate anaesthetic agent with minimum cardio respiratory depressant effect as compared to others (Paul et al 1982). It is in clinical use for more than ten years and used safely in aged and critically ill patients (Lorhan & Limppman 1971, Barson and Aren 1974). In sub-anaesthetic doses it has been safely used to produce obstetrical...
Journal of Near-Death Studies
1984
Debora Rogo
39 citations
The phenomenology that typically accompanies the near-death experience (NDE) is also sometimes a by-product of ketamine, an anesthetic used in both medical and recreational settings. Some surveys indicate that NDE-type ketamine hallucinations are quite common. The close parallels between some ketamine experiences and the NDE can be explained by a variety of conceptual models, including these:...
British Journal of Pharmacology
June 1, 1983
Nabil A. Anis, Stephen C. Berry, N.r. Burton et al.
1,415 citations
The interaction of two dissociative anaesthetics, ketamine and phencyclidine, with the responses of spinal neurones to the electrophoretic administration of amino acids and acetylcholine was studied in decerebrate or pentobarbitone-anaesthetized cats and rats. Both ketamine and phencyclidine selectively blocked excitation by N-methyl-aspartate (NMA) with little effect on excitation by...
JAMA
November 11, 1974
Miles K. Crowder
16 citations
To the Editor.— In a recent issue (229:763, 1974), Shaffer describes a series of cases characterized by anesthesia, analgesia, nystagmus, dizziness, diplopia, visual distortions, and psychosis. These findings were attributed to ketamine, a derivative of phencyclidine. Phencyclidine is a major component of street drug preparations.1In one series, phencyclidine was detected in 184 of 237 street...
Journal of Neurosurgery
October 1, 1972
Seth M. Weingarten
22 citations
✓ Studies in cats under ketamine anesthesia indicate a dissociation between the electrical activity of the thalamoneocortical areas and that of the ventral hippocampal structures. The medial area of the septum verum and the dorsal hippocampus react similarly to the thalamoneocortical circuit; however, the electrical activity of the septum verum has no direct relationship to that of the ventral...