Ketamine: all studies (page 200) - The Consciousness Library

A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers With PTSD and Depression

Frontiers in Psychiatry January 12, 2022 Shannon Dames, Pamela Kryskow, Crosbie Watler 38 citations

Amid an international pandemic and a worsening mental health crisis, ketamine-assisted therapy is emerging as a promising solution for those deemed “treatment resistant.” Post-traumatic stress disorder (PTSD) and depression are on the rise, with accelerating direct (e.g., burden of suffering) and indirect (e.g., disability/role impairment and impact on family) costs. Psychedelic-assisted...

DOI: 10.3389/fpsyt.2021.803279 Full text Psychedelic therapy Depression Ketamine-assisted psychotherapy Healthcare providers hcp +6

Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder

American Journal of Psychiatry January 11, 2022 Meryem Grabski, Amy Mcandrew, Will Lawn et al. 169 citations

OBJECTIVE: Early evidence suggests that ketamine may be an effective treatment to sustain abstinence from alcohol. The authors investigated the safety and efficacy of ketamine compared with placebo in increasing abstinence in patients with alcohol use disorder. An additional aim was to pilot ketamine combined with mindfulness-based relapse prevention therapy compared with ketamine and alcohol...

DOI: 10.1176/appi.ajp.2021.21030277 Ketamine Alcohol use disorder Placebo Relapse prevention +5

Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression

Translational Psychiatry January 10, 2022 F. Cathomas, L. Bevilacqua, Aarthi Ramakrishnan et al. 44 citations

Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD is associated with a pro-inflammatory state and that ketamine may inhibit inflammatory processes. We thus investigated whole blood transcriptional profiles related to TRD and...

DOI: 10.1038/s41398-021-01712-0 Full text

Guanosine boosts the fast, but not sustained, antidepressant-like and pro-synaptogenic effects of ketamine by stimulating mTORC1-driven signaling pathway.

European Neuropsychopharmacology January 7, 2022 A. Camargo, A. P. Dalmagro, Eslen Delanogare et al.

The mTORC1-dependent dendritic spines formation represents a key mechanism for fast and long-lasting antidepressant responses, but it remains to be determined whether this mechanism may account for the ability of guanosine in potentiating ketamine's actions. Here, we investigated the ability of ketamine plus guanosine to elicit fast and sustained antidepressant-like and pro-synaptogenic effects...

DOI: 10.1016/j.euroneuro.2021.12.010

Dynamic reconfiguration of frequency-specific cortical coactivation patterns during psychedelic and anesthetized states induced by ketamine

Neuroimage January 7, 2022 Duan Li, Phillip E. Vlisides, George A. Mashour 24 citations

Recent neuroimaging studies have demonstrated that spontaneous brain activity exhibits rich spatiotemporal structure that can be characterized as the exploration of a repertoire of spatially distributed patterns that recur over time. The repertoire of brain states may reflect the capacity for consciousness, since general anesthetics suppress and psychedelic drugs enhance such dynamics. However,...

DOI: 10.1016/j.neuroimage.2022.118891 Ketamine Wakefulness Consciousness Repertoire +1

Increase in thalamic cerebral blood flow is associated with antidepressant effects of ketamine in major depressive disorder

The World Journal of Biological Psychiatry January 5, 2022 Matti Gärtner, Mischa de Rover, Lena Václavů et al. 11 citations

Ketamine is a promising treatment option for patients with Major Depressive Disorder (MDD) and has become an important research tool to investigate antidepressant mechanisms of action. However, imaging studies attempting to characterise ketamine's mechanism of action using blood oxygen level-dependent signal (BOLD) imaging have yielded inconsistent results- at least partly due to intrinsic...

DOI: 10.1080/15622975.2021.2020900 Ketamine Major depressive disorder Antidepressant Cerebral blood flow +7

Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment.

Progress in Neuro-Psychopharmacology and Biological Psychiatry 2022 A. Camargo, A. C. N. Torrá, A. P. Dalmagro et al.

Ketamine enhances the resilience against stress-induced depressive-like behavior, but its prophylactic efficacy in anxiety-related behaviors remains to be elucidated. Moreover, there is a need for developing novel preventive strategies against depressive- and anxiety-like behavior. AZD6765, a low-trapping NMDA receptor antagonist, shares with ketamine common molecular targets and produces...

DOI: 10.1016/j.pnpbp.2022.110509

Use of intranasal esketamine in a girl with treatment-resistant depression and autism spectrum disorders: a case report.

EXCLI journal 2022 Miriam Olivola, Vincenzo Arienti, Nicola Bassetti et al.

Major depression is a common comorbidity in autism spectrum disorder (ASD), often difficult to identify and to treat. Autistic subjects are more at risk for suicidal thoughts and behaviors compared to typically developing peers. Unfortunately, ASD individuals are more frequently treatment-resistant and often show side-effects which reduce efficacy. Intranasal esketamine has been recently...

DOI: 10.17179/excli2022-4694 Full text Depression Esketamine Autism spectrum disorders Treatment-resistant

A single intravenous administration of a sub-anesthetic ketamine dose during the perioperative period of cesarean section for preventing postpartum depression: A meta-analysis.

Psychiatry Research 2022 Qiuwen Li, Sai-Ying Wang, Xi Mei

The feasibility of intravenous ketamine administration during the perioperative period of cesarean section to prevent postpartum depression (PPD) has not been determined by meta-analysis. To evaluate the efficacy, safety and dose of prophylactic ketamine in offsetting PPD, we retrieved the following databases in English or Chinese from inception to December 2020: Pubmed, Embase, Web of Science,...

DOI: 10.1016/j.psychres.2022.114396

The Myths of Uncontrolled Emergence Reactions and Consideration to Stop Mandatory, Protocolled Midazolam Coadministration With Ketamine.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals 2022 Hugh M Hiller, Brendon Drew, Andrew D Fisher et al.

Ketamine continues to demonstrate its utility and safety in the austere and prehospital environment, but myths persist regarding the frequency of behavioral disturbances and unpleasant reactions. These myths have led to protocolled midazolam co-administration. Properties of midazolam and other benzodiazepines have the potential to cause significant morbidity and potential mortality. Because of...

DOI: 10.55460/pngh-p2ck Full text