Chiara Rolle, Mario H W Scheib, Anja Frank et al.
1 citation
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The most reported symptom of post-COVID syndrome is pronounced fatigue (Malik et al., 2021; Venkatesan, 2021). In this case series, we present the treatment of four patients suffering from Post-COVID syndrome after more than 3 months since infection, presented diagnostically within the framework of chronic fatigue syndrome (CFS). They were treated with a combination of Low-frequency (1 Hz)...
Anja Frank, Mario H W Scheib
preprint
Introduction: Europe faces a worsening mental health crisis, with nearly half of the population (46%) reporting emotional or psychological issues, such as depression, within the last year. One in six Europeans is currently affected by mental health problems, equating to approximately 84 million individuals across the continent (Nawrocka, 2023). Method: This study examines the impact of a...
Viviana D. Evans, Alejandro Arenas, Kenneth Shinozuka et al.
preprint
Background: Ketamine, an arylcyclohexylamine dissociative anesthetic agent, has evolved into a versatile therapeutic. It has a rapid onset, well-understood cardiovascular effects, and a favorable safety profile in clinical use. Its enantiomeric compound, esketamine, was approved by the FDA in 2019 for both treatment-resistant depression as well as major depressive disorder (MDD) with suicidal...
Research Square
Jack Swain, Davis Carter, Leonardo Vando et al.
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Abstract Background Sleep disturbances are a significant public health burden affecting 50 to 70 million adults in the United States and contributing to impaired cognition, accelerated disease progression, and increased mortality risk. 1,2 Available pharmacological treatments carry notable safety and tolerability risks, while access to the leading evidence-based behavioral intervention,...
Zümrüt Duygu Sen, Nitin Sharma, Lena Vera Danyeli et al.
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Along with its rapid therapeutic benefits, ketamine induces transient experience of dissociation during administration. Given the suggested association between ketamine-induced dissociation and treatment response, understanding the neural correlates of dissociation would help to elucidate its therapeutic mechanism. The posteromedial cortex (PMC) has been reported to play a vital role in the...
Noam Goldway, Taly Markovits, Naomi Fine et al.
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Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of Post-Traumatic Stress Disorder (PTSD). Despite its significance, the neurocognitive processes underlying dissociation remain poorly understood, potentially limiting the effectiveness of PTSD diagnostics and treatment. To address this gap, we...
Research Square
Norihiro Okada, Kenshiro Oshima, Akiko Maruko et al.
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Abstract In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and...
Research Square
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
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Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with Major...
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al.
4 citations
preprint
Treatment resistant depression (TRD) is a tremendous health problem that has encouraged novel treatment strategies involving sub-anesthetic ketamine infusions. While ketamine induces rapid and sustained clinical improvement, its cognitive effects are less well known. Here we tested if ketamine alters the negative expectancies about the future that are insensitive to disconfirming information,...
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
1 citation
preprint
Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the safety of intravenous ketamine treatment concerning dissociative and psychotic measures in TRD inpatients with Major Depressive Disorder (MDD) and...