Basic & Clinical Pharmacology & Toxicology
December 2008
Lêda S B Garcia, Clarissa M Comim, Samira S Valvassori et al.
A growing body of evidence has pointed to the blockade of the N-methyl-d-aspartate (NMDA) receptor signaling as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with ketamine and imipramine in rats. To this aim, rats were 14 days treated once a day with ketamine (5, 10 and 15...
Journal of Palliative Medicine
November 2008
Lilianna Stefanczyk-Sapieha, Doreen Oneschuk, Michael Demas
Major Depressive Disorder (MDD) is prevalent in patients with advanced cancer, and can have a negative impact on patients' quality of life. Available antidepressants, often have delayed benefits of several weeks, and therefore are of limited utility in the palliative care setting. Psychostimulants provide more rapid onset of action, but frequently require dose escalation because of problems...
Schizophrenia Research
August 2008
Oliver J Mason, Celia J M Morgan, Ana Stefanovic et al.
This study reports a new measure of psychotomimetic states in the context of cannabis and ketamine use. The Psychotomimetic States Inventory (PSI) has sub-scales of Delusory Thinking, Perceptual Distortions, Cognitive Disorganization, Anhedonia, Mania and Paranoia. The PSI was administered in two independent group, repeated measures designs: an experimental study of ketamine and a naturalistic...
British Journal of Urology
August 1, 2008
Peggy Chu, Wai‐kit Ma, Simon Chun‐wing Wong et al.
363 citations
OBJECTIVE: To report the clinical spectrum seen in young abusers of street-ketamine (regular recreational abusers of street-ketamine, for its hallucinogenic effects) in Hong Kong, presenting with significant lower urinary tract symptoms (LUTS) but with no evidence of bacterial infection. PATIENTS AND METHODS: We retrospectively analysed the clinical presentations, pelvic pain and...
Journal of Medical Case Reports
June 26, 2008
Britt Colebunders, Peter Van Erps
Introduction: Ketamine is a derivative of phencyclidine and is a dissociative anaesthetic. Its use as a recreational drug is on the increase among young adults attending clubs and parties. Case presentation: We describe the case of a 20-year-old man who presented with a 7-month history of urinary frequency, nocturia, urgency, suprapubic discomfort during micturition and episodes of severe...
Human Psychopharmacology Clinical and Experimental
June 11, 2008
Alexander Heinzel, Rainer Steinke, Thorsten Dirk Poeppel et al.
22 citations
OBJECTIVE: We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. METHODS: We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and...
Psychopharmacology
June 2008
Piotr Popik, Tomasz Kos, Magdalena Sowa-Kućma et al.
We investigated the immediate and enduring effects of ketamine in behavioral and neurochemical assays predictive of antidepressant activity. One week after a single administration of ketamine (50-160 mg/kg), otherwise experimentally naive rats and mice were tested either in the forced swim test (FST) or the tail suspension test (TST). Other mice were also tested twice in the FST: immediately...
Addiction Research & Theory
June 1, 2008
Sit Down to Float: The Cultural Meaning of Ketamine Use in Hong Kong.
Journal of Neuroscience
June 1, 2008
Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo.
Journal of Neuroscience
May 14, 2008
Wulf Hevers, Stephen H Hadley, Hartmut Lüddens et al.
Phencyclidine (PCP) and ketamine are dissociative anesthetics capable of inducing analgesia, psychomimetic behavior, and a catatonic state of unconsciousness. Despite broad similarities, there are notable differences between the clinical actions of ketamine and PCP. Ketamine has a lower incidence of adverse effects and generally produces greater CNS depression than PCP. Both noncompetitively...