Pentobarbital-like electroencephalographic rubral rhythm induced by ketamine in rabbits.
S Sagratella, A Scotti de Carolis
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1989 DOI: 10.1016/0278-5846(89)90023-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative experimental animal study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | Ketamine Pentobarbital Pentylenetetrazol Phencyclidine SKF 10.047 Cyclazocine CCP |
| Dose | Ketamine 10 mg/kg i.v.; pentylenetetrazol 10 mg/kg i.v. |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine (10 mg/kg i.v.) produced a pentobarbital-like rhythmic EEG change in the rabbit red nucleus that was blocked by the GABA antagonist pentylenetetrazol (10 mg/kg i.v.), whereas phencyclidine, SKF 10.047, cyclazocine, and CCP did not affect baseline red nucleus activity. The authors conclude that ketamine interacts with GABA neurotransmission in the cerebello-rubral pathways, unlike the other PCP/sigma opiates tested. |
Abstract
1. The effects caused by the dissociative anaesthetic drugs (PCP, KT), the sigmaopiates (SKF 10.047, cyclazocine), and the mixed excitatory amino acid antagonist CCP on the electrical activity of the red nucleus in rabbits were compared with PB. 2. Ketamine (10 mg/kg, i.v.) induced the appearance of a pentobarbital-like EEG synusoidal rhythm characterized by an increase in amplitude and a decrease in frequency of the basal electrical activity at the red nucleus level. 3. Both pentobarbital and ketamine induced rhythms were blocked by the GABA-antagonist pentylenetetrazol at the subconvulsant dose of 10 mg/kg, i.v. 4. Phencyclidine, SKF 10.047, cyclazocine, and the mixed excitatory amino acid antagonist CCP failed to affect the basal electrical activity of the red nucleus. 5. These data indicate an interaction of ketamine on the GABA neurotransmission at the level of cerebello-rubral pathways which the other PCP/sigma opiates did not present.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 2
- The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate British Journal of Pharmacology June 1, 1983
- Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior. Journal of Pharmacology and Experimental Therapeutics October 1, 1985