Dissociation of limbic and neocortical EEG patterns in cats under ketamine anesthesia
Journal of Neurosurgery October 1, 1972 DOI: 10.3171/jns.1972.37.4.0429 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Cats under ketamine or barbiturate anesthesia |
| Interventions | Ketamine Barbiturates |
| Topics | Esketamine Ketamine |
| Citations | 22 |
| Key findings | Ketamine anesthesia dissociates electrical activity between thalamoneocortical areas and the ventral hippocampus in cats, a pattern not seen with barbiturates. |
Abstract
✓ Studies in cats under ketamine anesthesia indicate a dissociation between the electrical activity of the thalamoneocortical areas and that of the ventral hippocampal structures. The medial area of the septum verum and the dorsal hippocampus react similarly to the thalamoneocortical circuit; however, the electrical activity of the septum verum has no direct relationship to that of the ventral hippocampal structures. Another group of cats under barbiturates did not show this dissociation in the EEG. It is suggested that the trance-like state of patients undergoing ketamine anesthesia and the hallucinatory experience in the early recovery phase may be related to the dissociated effects of the drug on the limbic and neocortical systems of the brain.
Comparable studies
Other observational and cohort studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Taming the Ketamine Tiger Volunteers from a prison population | 2010 | Observational study | n = 20 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Disruption of Frontal–Parietal Communication by Ketamine, Propofol, and Sevoflurane Surgical patients undergoing induction of anesthesia with intravenous ketamine | 2013 | Observational cohort | n = 30 |
| Do the dissociative side effects of ketamine mediate its antidepressant effects? Treatment-resistant inpatients with major depressive disorder or bipolar disorder | 2014 | Observational cohort | n = 108 |
| Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder Patients with treatment-resistant major depressive disorder | 2012 | Observational cohort | n = 30 |