MedicineMay 2, 2025Xiaobo Bi, Junchao Dai, Jin Li8 citations
This study aimed to investigate the effects of a single intravenous injection of esketamine during general anesthesia on postoperative anxiety and depression in patients with thyroid cancer. In this randomized, double-blind, placebo-controlled, parallel-group trial, eighty female patients with thyroid cancer were scheduled to undergo surgery under general anesthesia. The patients were randomly...
SleepMay 1, 2025Mika Hirata, Heba A Afaneh, Ishana Kapoor et al.
Perinatal women are highly vulnerable to insomnia and depression. High cognitive arousal (e.g., worry, rumination) at night is a key risk factor for developing insomnia and depression during this period. However, mindfulness skills have been proposed to reduce risk for negative health outcomes by protecting individuals against the harmful effects of cognitive arousal. This prospective study...
SUMMARYThis critical appraisal of a Cochrane Review assesses the efficacy of ketamine for treating unipolar major depressive disorder. The review included 31 randomised controlled trials involving ketamine. Results indicate that intravenous (i.v.) ketamine significantly improves antidepressant response compared with i.v. saline and, to a lesser extent, i.v. midazolam within 24–72 h. However,...
There is a dearth of meta-analytical studies measuring the durability of mindfulness-based cognitive therapy (MBCT) in the treatment of anxiety and depressive disorders. Therefore, the present study was conducted to evaluate both the effectiveness and durability of MBCT in the treatment of depression and anxiety disorders. We systematically searched six databases from June 11, 2023 to September...
Interventions to cope with emotional states (depression, stress, and anxiety) and strengthen attachment are important. This research aims to determine the effect of the Mindfulness-Based Childbirth and Parenting Program (MBCP) on pregnant women's prenatal attachment and their levels of depression, stress, and anxiety. This randomized controlled trial included 36 participants who were randomly...
Nasopharyngeal carcinoma (NPC) presents a substantial challenge for patients, impacting their physical and psychological well-being. Patients may experience moderate depression, anxiety, and reduced quality of life due to the disease and its treatments. Therefore, we retrospectively analyzed the adjunctive therapeutic potential of mindfulness-based stress reduction (MBSR) therapy for NPC...
Mindfulness-based interventions have shown promise in alleviating symptoms associated with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). However, the specific mechanisms that drive these effects, mainly through obsessive beliefs and mental well-being, are seldom examined. To explore the mechanisms by which mindfulness influences symptom severity in adults with...
Postpartum depression (PPD) is an increasingly prevalent but still poorly characterized disorder. Causal and modulating factors include hormones fluctuations, such as estrogen, progesterone, and allopregnolone, pathways imbalances, such as oxytocin and kynurenine, chronobiological factors, and brain imaging alterations. Treatment may differ from the traditional major depression management,...
This systematic review and network meta-analysis (NMA) sought to compare different antidepressant treatments for treatment-resistant depression (TRD) in order to facilitate evidence-based choices. A literature search of PubMed, Cochrane Library, and Embase from inception until April 13th, 2023 identified randomized, controlled trials (RCTs) of adults with depression who had not responded to at...
Ketamine's use in treating bipolar depression must account for risks, such as switching to manic episodes or worsening symptoms. This study examines ketamine's impact on depressive symptoms, focusing on 'inner tension,' 'sleep reduction,' and 'suicidal ideation' over four weeks in treatment-resistant bipolar disorder (TR-BD) patients. Fifty-nine patients with TR-BD were treated consecutively...