Frontiers in Psychiatry
May 8, 2025
Yanping Lu, Longxin Dang, Yuan Tao
Cyberbullying victimization (CV) has been linked to numerous adverse psychological outcomes among adolescents. While previous research has established associations between CV and negative outcomes including depression, diminished self-esteem, and academic burnout, the potential protective mechanisms in these relationships remain underexplored. This longitudinal study investigated the mediating...
Journal of Neonatal Surgery
May 8, 2025
Rachna Garg, Shubhagata Awasthi, Naveen Gupta
This study investigates the effectiveness of a 10-week Mindfulness-Based Cognitive Behavioral Therapy (MBCBT) intervention in reducing symptoms of depression, anxiety, and stress among elderly individuals. Psychological distress is increasingly prevalent in older adults, yet non-pharmacological interventions remain underutilized in geriatric care. Employing a quasi-experimental pre-post design,...
Psychopharmacology
May 8, 2025
Agnieszka Pałucha-Poniewiera, Anna Rafało-Ulińska, Agata Faron-Górecka et al.
1 citation
(S)-Ketamine, which is used to treat depression, has significant undesirable effects and has potential for abuse. A safe alternative to (S)-ketamine is (R)-ketamine. The relationship between (R)-ketamine and the mGlu5 receptor is unknown, although screening tests indicate the possibility of potentiation of the antidepressant effect of (R)-ketamine by the mGlu5 receptor negative allosteric...
Journal of reproductive and infant psychology
May 7, 2025
Izaskun Orue, Oiana Echabe-Ecenarro
1 citation
Perinatal anxiety and depression are significant public health concerns with the potential to affect maternal and infant well-being; therefore, it is crucial to identify protective factors. This study explores the reciprocal relationship between dispositional mindfulness and symptoms of anxiety and depression throughout pregnancy and the postpartum period. In a sample of 347 women, mindfulness...
American Journal of Psychiatry
May 7, 2025
Matthew B. Wall, Lysia Demetriou, Bruna Giribaldi et al.
16 citations
Despite large improvements in depressive symptoms in the psilocybin group, psilocybin therapy had only a minor effect on brain responsiveness to emotional stimuli. These results are consistent with prior findings that the antidepressant action of SSRIs is often accompanied by a reduction in emotional responsiveness, but this effect may not occur in psychedelic therapy.
Research Square
May 6, 2025
Zitong Wang, Brett Robbins, Ryan Zhuang et al.
preprint
Abstract Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third of MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly is due to the multifaceted etiology of TRD, encompassing biological, psychological, and...
Scientific Reports
May 6, 2025
Nahathai Wongpakaran, Sirilux Klaychaiya, Chompimaksorn Panuspanudechdamrong et al.
2 citations
Older adults frequently face a myriad of physical and mental health challenges, which can contribute to feelings of stress and subsequent depression. Nevertheless, with age often comes a wealth of life experience and resilience. Perceived stress commonly predicts depression across all age groups, while meditation has been associated with lower levels of depression. Additionally, adherence to...
Current Treatment Options in Psychiatry
May 5, 2025
Ana Malta Gomes, Filipa Novais
3 citations
Abstract Purpose of the review Treatment-resistant depression (TRD) is a challenging condition characterized by minimal improvement despite two or more antidepressant trials. Ketamine-assisted psychotherapy (KAP) integrates the rapid antidepressant effects of ketamine with psychotherapy to enhance and sustain therapeutic outcomes. This systematic review evaluates the effectiveness of KAP in...
Mindfulness
May 3, 2025
Shaun Hancock, Tharshanah Thayabaranathan, Rene Stolwyk et al.
Movement-based mindfulness may be beneficial for mental health and health-related quality of life (HRQoL) post-stroke. We assessed changes in anxiety, depression, fatigue, and HRQoL in survivors of stroke participating in movement-based mindfulness intervention against an attention control (social group). Participants were between 3- and 18-months post-stroke and randomised 1:1 to the...
The European Journal of Psychiatry
May 2, 2025
Josep Antoni Ramos‐quiroga, Fernando Mora, Silvia Arostegui et al.
4 citations
Pharmacological management of major depressive disorder has traditionally relied on antidepressants targeting the monoaminergic pathway. Treatment-resistant depression (TRD) patients have been frequently excluded from registrational trials, resulting in a lack of clear clinical recommendations for an optimised management. In recent years, treatments based on other mechanisms of action have been...