Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...
A large number of studies have demonstrated the effectiveness of mindfulness- based cognitive therapy (MBCT) in the adjuvant treatment of depression, and the significant effect of MBCT in inhibiting the recurrence of depression, most of these studies are randomized controlled trials. These studies compared a group of MBCT combined with conventional treatment and conventional treatment to ensure...
Depression has become a critical mental health issue, especially among college students, with increasing prevalence worldwide. According to the World Health Organization (WHO), approximately 322 million people globally suffer from the condition, with a prevalence rate of around 3.7% in Indonesia. This research examines the effectiveness of spiritual mindfulness therapy in reducing depression...
Our study sought to evaluate whether increased mindfulness and social support mediated the effect of the Amigas Latinas Motivando el Alma (ALMA) intervention on depression and anxiety among Latina immigrant women. The study was a secondary analysis of data from a trial evaluating the ALMA intervention with a delayed-intervention comparison group design. Latina immigrants (n = 226) were...
Abstract Objective Ketamine and esketamine have both shown significant antidepressant effects in treatment-resistant depression (TRD) and conflicting evidence suggests that dissociation induced by these drugs could be a clinical predictor of esketamine/ketamine's efficacy. Methods This study is a secondary analysis of data from a two-center, randomized, controlled trial. Participants were...
Mindfulness has been consistently linked to mental health benefits; however, the underlying mechanisms relating mindfulness to life satisfaction and depression remain underexplored. This study develops and empirically examines the Dual Pathways Mindfulness Model (DPMM), which posits that mindfulness is associated with mental health through sequential mechanisms involving self-compassion and...
medRxivMay 27, 2025Colin G Walsh, Michael Ripperger, Thomas H McCoy et al.
preprint
As multiple strategies have emerged for managing treatment-resistant major depressive disorder, efficient identification of individuals at elevated risk for this outcome earlier in their illness course remains essential. We extracted electronic health records data for all individuals with a diagnosis of major depressive disorder who received an index antidepressant prescription in the clinical...
Over the past years, a number of clinical and preclinical investigations have been documented, suggesting treatment strategies and pharmaceuticals for neuropathic pain and depressive disorders, potentially beneficial in cases where these conditions are comorbid. This review lists these potential treatment options and discusses the proposed underlying mechanisms of action and their limitations,...
Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third of MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly is due to the multifaceted etiology of TRD, encompassing biological, psychological, and environmental...
Mindfulness, defined as the ability to be fully aware and attentive to the present moment without judgment, has sparked growing interest in the therapeutic approach to anxiety disorders and depression. The objective of this narrative review is to provide a historical overview of the definition of mindfulness, the clinical implications of this practice based on Buddhist philosophy, and analyze...