MoleculesJanuary 8, 2026Anna W Sobańska, Andrzej M Sobański, Elżbieta Brzezińska1 citation
A total of 250 known and novel compounds-ketamine and serotonergic psychedelics or their analogues-designed to target depression, addictions and/or other mental or neurological disorders and developed as "recreational" (illegal) drugs from three chemical families, ergolines, tryptamines and phenylethylamines, were investigated in the context of their ability to cross the human placenta. Using a...
The lifetime prevalence of mood disorders such as major depressive disorder (MDD) is thought to approach up to 50% of the world's population. Traditionally, research into the mechanisms of these disorders has focused on neurotransmission, but emerging evidence highlights neuroimmune interactions-the molecular signaling between immune and brain cells-as key regulators of brain plasticity,...
Clinical ToxicologyJanuary 6, 2026D. Jorgenson, Eliezer Santos León, J. Priyanka Vakkalanka et al.1 citation
INTRODUCTION: Psychoactive mushroom edibles are gaining popularity, yet little is known of their clinical effects. These unregulated products are widely available, often with unlisted ingredients and inconsistent formulations, underscoring the need for more research to address public health concerns. We aimed to investigate recent trends in demographics and clinical effects associated with...
Abstract Background and Aims Parkinson's disease (PD) significantly impairs quality of life, and current treatments do not halt dopaminergic neurodegeneration. Evidence suggests that ibogaine, a naturally occurring indole alkaloid, may stimulate glial cell line-derived neurotrophic factor (GDNF) expression and affect dopamine transporter (DAT) function. This case study reports the effects of...
Adolescent mental health conditions, particularly treatment-resistant depression (TRD), represent a growing public health challenge associated with high morbidity, functional impairment, and elevated suicide risk. Psychedelic-assisted therapies have shown robust antidepressant and transdiagnostic effects in rigorously controlled adult trials. Extending this work to adolescents is scientifically...
Background: Psilocybin has shown rapid and sustained antidepressant effects in patients with major depressive disorder, yet the neurobiological mechanisms underlying these outcomes remain unclear. Aims: This study aimed to bridge clinical and preclinical findings by investigating the relationships between 5-HT 2A receptor occupancy (RO) achieved after administration of psilocybin and its...
Abstract Breathwork techniques such as diaphragmatic, paced, and box breathing are increasingly used in psychotherapy and embodied clinical practice yet their efficacy and mechanisms remain unevenly documented. This systematic review and meta-analysis synthesised controlled studies examining breathwork as a stand-alone or adjunctive intervention for psychological (anxiety, depression, stress)...
Mindfulness-based stress reduction (MBSR) has been shown to improve mental health and well-being in people with different medical conditions. However, whether it improves outcomes in chronic stroke populations is less clear, as few studies have examined the efficacy of MBSR in this population with a randomized controlled trial and an active control condition. Our study aimed to address this...
Background: Ketamine, a dissociative anaesthetic and non-competitive NMDA receptor antagonist, has legitimate medical applications. However, rising illicit use across the United Kingdom (UK) has been accompanied by growing reports of toxicity, dependence, and deaths. These have led to renewed policy discussions. Rationale and Aim: Previous national studies have reported ketamine-related deaths...
Tai Chi has evolved into a widely used mind-body practice increasingly incorporated into complementary therapy, rehabilitation, and public health. This study provides an updated global bibliometric overview, with VOSviewer mapping publication performance, co-authorship networks, and keyword-based thematic clusters. Articles and reviews with Tai Chi-related terms in the title were retrieved from...