Healthcare
January 16, 2026
Denis Juraga, Darko Roviš, Mihaela Marinović Glavić et al.
Background: Aging is a complex process that involves various biological, psychological and social changes. Moreover, older people (≥65 years) are more susceptible to lower self-efficacy and social support, as well as deteriorating mental health. As the global population ages, there is a growing demand for evidence-based interventions tailored to address specific mental health problems, enhance...
bioRxiv : the preprint server for biology
January 16, 2026
Fernanda Daher, Caio T Fukushima, Erik A Ingebretsen et al.
1 citation
preprint
Chronic stress disrupts glutamatergic and GABAergic plasticity in the medial prefrontal cortex (mPFC), impairing circuit integration and contributing to the pathophysiology of stress-related disorders, such as Major Depressive Disorder (MDD). Rapid-acting antidepressants like ketamine can rapidly reverse these deficits, but its clinical use is limited by psychotomimetic side effects. Notably,...
Journal of Gastroenterology & Hepatology Reports
January 15, 2026
Ven Dr. Sumedh Thero
Older adults underestimate their level of life stress and early adversity, and kind of the impact that has. For some people, early adversity can affect their entire lives, but for other people, it seems like it catches up to them once they’re aging. our frontal lobes helping moderate our emotional responses. But the frontal lobes are also one of the main areas of the brain that begins to...
Journal of Education, Innovation, and Communication.
January 15, 2026
Gina Solano
Anxiety in young children has increasingly become a significant concern for classroom teachers in recent years. This issue not only disrupts the learning environment but also contributes to a range of other health-related problems. If left unaddressed, childhood anxiety can lead to long-term mental health issues such as depression and social isolation, as children become accustomed to coping...
bioRxiv (Cold Spring Harbor Laboratory)
January 15, 2026
Justyna K. Hinchcliffe, Christopher W. Thomas, Gary Gilmour et al.
preprint
Abstract The serotonergic psychedelic, psilocybin, shows potential for rapid and sustained antidepressant effects but the underlying mechanisms remain unknown. Using a chronic interferon-alpha–induced rat model of depression, we show acute psilocybin (0.3 mg/kg) reverses impaired reward-induced biases within 24hrs, with effects enduring for at least 7 days. This suggests psilocybin can restore...
bioRxiv Preprint Server
January 14, 2026
Muad Y. Abd El Hay, Ana Cukić, Marieke Schölvinck et al.
preprint
Psychedelic substances show promise for treating psychiatric disorders including depression, anxiety, and PTSD, but the neurobiological mechanisms underlying their therapeutic effects remain poorly understood. Preclinical findings have so far been inconsistent, limiting mechanistic insights. We argue this translational gap is exacerbated by systematic disconnects between conditions thought to...
Psychiatric Research and Clinical Practice
January 14, 2026
Celia Faye Jacobsen, Dea Siggaard Stenbæk, Stig Poulsen et al.
3 citations
A key distinction among clinical trials on psilocybin treatments, for example, those targeting depression, has been whether the psilocybin dosing session is combined with bona fide psychotherapy or with what is referred to as “psychological support” (1-3). The most developed model of psychological support is the Compass Psychological Support Model (CPSM; 1). Kirlić and colleagues specifically...
January 13, 2026
David Rosen, Frederick S. Barrett, Albert Garcia‐romeu et al.
preprint
Personally meaningful music can evoke vivid emotions and autobiographical memories, reconnecting listeners with their personal past. Whether the autobiographical salience of music, as distinct from familiarity, modulates its effects on an individual’s state of consciousness has not been systematically tested. We compared autobiographically salient (AS) music with a standardized therapeutic...
Behavioral Sciences
January 13, 2026
Victor Julián Padilla, Vanessa Muñiz, Katherine Scheffrahn et al.
Mindful hypnotherapy is an intervention that integrates hypnotic induction and direct suggestions (hypnosis) to increase mindfulness and reduce distress. In the present study, a systematic review and meta-analysis were conducted to investigate the effects of mindful hypnotherapy on psychological distress and mindfulness in adults. Further, the study evaluated the methodological quality of the...
Healthcare
January 13, 2026
Andrea Lizama-Lefno, Krystel Mojica, Mayte Serrat et al.
The rapid expansion of mindfulness research has generated both enthusiasm and controversy regarding its actual clinical value. While meditation is often regarded as the central mechanism of mindfulness-based interventions, other components such as psychoeducation and informal practice may play an equally significant role in improving mental health outcomes. This critical review examines the...