The escalating global burden of mental health disorders, coupled with the stagnation of innovation in traditional monoaminergic pharmacotherapy (e.g., SSRIs), has precipitated a critical need for novel therapeutic paradigms. This article presents a comprehensive systematic review of the so-called "Psychedelic Renaissance," focusing on the clinical resurgence of classical serotonergic...
This study aimed to test the effectiveness of Mindfulness-Based Cognitive Therapy for Procrastination (MBCT-P) in reducing academic procrastination, as well as explain how MBCT-P can reduce academic procrastination. The research participants were 43 Muslim university students with academic procrastination scores in the medium and high categories who were randomly divided into the experimental...
Introduction Transgender and gender-expansive people experience high rates of depression, anxiety, and trauma-related distress, yet few evidence-based interventions are tailored to their needs. Kindred is a novel, group-based ketamine-assisted psychotherapy (KAP) program that integrates cognitive processing therapy (CPT) to address identity-based trauma. Methods This mixed-methods pilot study...
Treatment-resistant depression (TRD) poses a major challenge in research and clinical practice. Various guidelines recommend different pharmacological approaches. While lithium and second-generation antipsychotics have traditionally been the drugs of choice in cases of medication resistance, recent years have seen increasing evidence for the efficacy of esketamine as a fast-acting agent against...
CureusJanuary 21, 2026Ron Gabriel A Peji, Diane D Lipat, Alyssia M de Rojas
Trauma-related perceptual experiences may resemble psychotic symptoms, creating diagnostic challenges in adolescent populations. We report the case of a Filipino preadolescent female diagnosed with posttraumatic stress disorder (PTSD) and major depressive disorder following prolonged intrafamilial sexual abuse. During trauma-focused psychotherapy incorporating expressive techniques, the patient...
Psilocybin has been reported to decrease depression symptoms among individuals with bipolar disorder (BD), but has also been associated with reports of mania, psychosis and increased depression. With increasing recreational use of psilocybin, and the potential for psilocybin to be used as a treatment for depression, a better understanding of the risks and benefits of this psychedelic among...
CNS DrugsJanuary 17, 2026Gaëlle Rached, Anna Campana, Dimitri Fiani et al.1 citation
Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric conditions, despite potentially serious drug-drug interactions and associated dietary tyramine restrictions. However, they are rarely prescribed in patients with comorbid substance use disorders (SUDs) due to concerns about potential drug interactions and...
Abstract Introduction The wellbeing of university undergraduates is a pressing area of concern, with one in five students reporting serious psychological distress. In previous semesters of a course on mental wellbeing, we asked undergraduates to engage with a standardized wellness program for the general population and provide feedback through weekly surveys and a final reflection paper. Based...
Psilocybin-assisted therapies are increasingly studied for Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD), and methodological rigor requires both pharmacological evaluation and consistent reporting of non-pharmacological variables that influence therapeutic outcomes. To address this need, the ReSPCT (Reporting of Setting in Psychedelic Clinical Trials) guidelines were...