Quality in SportJanuary 31, 2026Anna Maria Komarczewska, Filip Matusiak, Klaudia Brzoza et al.
Psilocybin-assisted interventions have shown rapid reductions in depressive symptoms in controlled clinical settings, raising questions about biological mechanisms supporting durability beyond the acute drug effect. [5,7] Mechanistic accounts increasingly focus on neuroplasticity as a candidate pathway linking transient serotonergic receptor activation to longer-lasting psychological and...
Trait mindfulness refers to an individual’s inherent capacity to maintain sustained awareness and focus on present experiences. This characteristic is naturally present in the population, even without intentional mindfulness training, and is significantly negatively correlated with negative emotions, anxiety, and depression. Fear is an adaptive response to threat, but excessive generalization...
Psycho-spiritual distress is prevalent and distressing among advanced cancer patients. While mind-body exercises have shown promise in alleviating psychological distress, their effectiveness in advanced cancer patients is still being explored. This study aimed to explore the feasibility and acceptability, and preliminary efficacy of two mind-body exercises-Tai Chi and mindful yoga-each rooted...
Repeated exposure to ketamine leads to mental behavioral disorders and cognitive deficits in mice. As a neurotransmitter receptor, dopamine receptor 1 (DRD1) is involved in mental regulation and memory formation. However, the role of DRD1 in ketamine's behavioral disorder and neurotoxicity remains unclear. We found that seven-day ketamine exposure induced anxiety-like, depressive-like behavior...
Palliative MedicineJanuary 30, 2026James Downar, Julie Lapenskie, Koby Anderson et al.
Background: Psychological distress is a common problem near the end of life, for which we lack effective, timely and scalable treatments. No previous study has assessed whether microdose psilocybin can improve symptoms in this population. Aim: To determine whether microdose psilocybin is safe, feasible and potentially efficacious in a palliative setting. Design: Open label, single-arm clinical...
American Journal on AddictionsJanuary 28, 2026Mariana C De Oliveira, Cláudia C De Araujo Palmeira, André B Negrão et al.1 citation
Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25-year-old woman with OUD, chronic pain, and major depressive disorder underwent an 8-week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering. Methadone dosage was reduced by 50%, with improved pain and craving control,...
PathophysiologyJanuary 27, 2026Fiorela Gorea, Martina Pelle, Federico Fiori Nastro et al.
Background/Objectives: Cannabis use has a particularly high prevalence in individuals with psychotic disorders. Although cannabis use is generally associated with cognitive impairments in the general population, its impact on cognition in psychosis remains controversial. This study aimed to investigate the association between cannabis use and cognitive performance in a cohort of individuals...
NeuroscienceJanuary 26, 2026Batoul Darwish, Jad El Masri, Lina Hourieh et al.
Neurogenesis in the adult brain is a precisely regulated process that remains highly sensitive to intrinsic and extrinsic influences. Among the external factors are psychological conditions, such as post-traumatic stress disorder (PTSD), which arises after exposure to trauma such as war, accidents, violence, or natural disasters. PTSD, as well as other disorders like stress and depression, has...
Background/Objectives: Sensory deprivation, defined as a reduction or absence of external sensory input across one or more modalities, has long been investigated in extreme and experimental settings. More recently, its relevance has expanded to clinical contexts and environmental conditions. The present narrative review aims to synthesize current evidence on the neurobiological mechanisms,...
To investigate whether a structured mindfulness training program could reduce anxiety and enhance academic performance among veterinary students in an anesthesiology course. All students enrolled in a second-year veterinary anesthesiology course during 1 term were offered participation in the mindfulness program, with volunteers forming the intervention group and nonparticipants serving as a...