Ketamine, a non-competitive N-methyl-D-aspartate acid (NMDA) receptor antagonist, produces rapid and sustained antidepressant actions, but the underlying molecular mechanism remains unclear. The CX 3 CL1/CX 3 CR1 signaling is closely related to mood disorders, and this study aims to investigate its role in ketamine’s antidepressant actions. We pharmacologically (AZD8797, a selective CX 3 CR1...
Substance use disorders (SUD) involving ketamine, cocaine, and alcohol present significant clinical challenges, often characterized by high relapse rates and limited pharmacological options. This case report details a 30-year-old male with a five-year history of severe polysubstance dependence, including daily intranasal ketamine use (2–3 g/day), cocaine, and alcohol, comorbid with recurrent...
Jurnal NersJuly 19, 2026Rivani Nur Oktavia, Regyta Marshanda, Budi Widiyanto
Whipping pink inhalation (recreational Nitrous oxide/N₂O) is increasingly popular on social media and is often perceived as safe. However, repeated exposure can trigger neurological emergencies such as peripheral neuropathy, myelopathy due to vitamin B12 deficiency, and respiratory disorders in the form of acute hypoxia and respiratory depression. Digital misinformation has the potential to...
Open MindJuly 19, 2026Eirini Karakasidou, Athina Komninou, Markella Kotzia
preprint
Study type: Randomized, controlled, parallel-group trial (retrospective registration; data collection already complete). Rationale/Background: University students training in psychology face elevated academic and emotional demands that place them at risk for stress, anxiety, and depression. This study examined whether a brief self-compassion and mindfulness training program could improve...
Intranasal ketamine represents a rapid and minimally invasive antidepressant strategy, yet the molecular mechanisms underlying its antidepressant-like effects after intranasal administration remain incompletely understood. Male Sprague-Dawley rats were subjected to a 28-day chronic unpredictable mild stress (CUMS) paradigm and then received intranasal racemic ketamine at 8.58 mg/kg twice weekly...
This chapter offers research-based methods for integrating Mindful Self-Compassion (MSC) into law school curricula and professional development. Meta-analyses and other empirical studies demonstrate that MSC enhances resilience, reduces depression and anxiety, mitigates burnout, fosters interpersonal connection, and supports peak performance. MSC complements widely practiced mindfulness...
Objectives: Mindfulness-integrated Cognitive Behavior Therapy (MiCBT) is an evidence-based, structured, transdiagnostic program. This study investigated three interrelated questions: (a) which characteristics predict initial enrolment suitability following intake assessment. (b) which baseline characteristics predict clinical improvement during MiCBT, (c) which characteristics predict treatment...
Objective: The objective of this narrative review is to understand what forms of spirituality screening and spiritual support are available to individuals with serious or life-threating illness involved in psychedelic-assisted therapies. Introduction: In addition to physical pain related to disease and treatment processes, people encountering serious illness frequently experience psychological...
Suicide remains a leading cause of premature mortality worldwide. Current treatments are limited by delayed onset, durability, or poor tolerability. This narrative review, informed by a structured literature search, summarises the last decade of evidence on pharmacological and neuromodulation interventions for suicidal ideation (SI) or suicide attempt (SA) that are not approved for these...
The modern quest for psychological well-being increasingly draws from both scientific and spiritual traditions. This proposed chapter explores how mindfulness, rooted in Eastern esotericism, and cognitive-behavioral approaches, grounded in Western psychology, converge to foster resilience and emotional balance among elderly populations. With age-related transitions often accompanied by...