Near-death experiences (NDEs) occasionally include claims of veridical perception — accurate information about the physical environment obtained from a reported out-of-body vantage point, ostensibly without ordinary sensory access. The largest attempt to test this directly (the AWARE I/II studies) placed hidden visual targets, visible only from a ceiling-level vantage point, in resuscitation...
Objective: The objective of this narrative review is to understand what forms of spirituality screening and spiritual support are available to individuals with serious or life-threating illness involved in psychedelic-assisted therapies. Introduction: In addition to physical pain related to disease and treatment processes, people encountering serious illness frequently experience psychological...
Open Science FrameworkJuly 9, 2026Raul Edison Luna Lazo, Nicole Milagritos Cardoso Azorza, Jatziri Yanina Vilca Yanac et al.
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Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition characterized by intrusive thoughts and repetitive behaviors that cause distress and functional impairment worldwide. Although selective serotonin reuptake inhibitors and cognitive behavioral therapy are first-line treatments, a considerable proportion of patients show an insufficient response, supporting the need for...
Open Science FrameworkJuly 5, 2026Dante Sebastián Galván Rial, Panagiotis Fotiadis, Marina Dauphin et al.
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Understanding how different states of consciousness arise from brain activity remains a central challenge in consciousness science. Theoretical and empirical work has increasingly linked conscious states to the large-scale organization and dynamical complexity of brain activity, using measures ranging from network integration and graph-theoretical properties to signal diversity, perturbational...
Self-compassion is theorized to play a central role in promoting mental health and wellbeing, including for individuals with social anxiety disorder (SAD). One proposed mechanism of MDMA-assisted therapy (MDMA-AT) for SAD is the cultivation of self-compassion. Across five aims, we will characterize self-compassion experiences during MDMA-AT and evaluate its role as a potential mechanism of...
This preregistration documents an update and extension of a meta-analysis of ketamine and esketamine for adults with treatment-resistant major depressive disorder (TRD). The project is nested within an existing network meta-analysis for TRD (NMA-TRD) project, which has already been fully specified and registered: • Muit et al., BMJ Open 2022 – protocol for a systematic review and network...
We investigate how the dose of psilocybin truffles and participant characteristics (trait absorption and expectations) influence subjective experiences and neurophysiological outcomes in a naturalistic field setting.The aim is to replicate observed effects of psilocybin from lab-based and clinical studies in a field / naturalistic setting.
This study examines the existence and mechanistic underpinnings of lasting neural, cognitive, and behavioural plasticity in response to N-N-dimethyltryptamine (DMT) in a hazardous drinking population. It combines behavioural, neuroimaging, ecological momentary and qualitative data to gain a holistic understanding of potential mechanisms of therapeutic change following DMT. Primarily, we test...
This project investigates the acute effects of psilocybin on probabilistic reinforcement learning in healthy adults. Using a double blind, randomized, within-subject, placebo-controlled design, we will analyze behavioral data and Event-Related Potentials (ERPs) from EEG recordings to understand how psychedelics modulate neural mechanisms of reward processing and decision-making.
Open Science Framework2025Mackenzie Hancock, Shambhu Prasad Adhikari, Nicole Getz
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This scoping review examines the emerging evidence for psilocybin-assisted therapy (PAP) in treating trauma-related disorders such as posttraumatic stress disorder (PTSD), depression, and persistent post-concussion symptoms (PPCS), with specific implications for intimate partner violence (IPV)-related brain injury and PTSD. Guided by PRISMA-ScR methodology, we systematically searched Medline,...
This rapid review aims to synthesise recommendations and statements from international clinical guidelines, consensus statements, and position statements regarding the medical use of psilocybin-assisted psychotherapy (PAP) in adults living with depression.