11 papers in the library · publishing 2025-2026
Open Science Framework September 7, 2026
如果一项技术能给你"永生"，条件是你接受全脑扫描、然后肉体被销毁——你会按下那个按钮吗？ 本文主张，多数人对这个问题的本能退缩完全理性：扫描—摧毁不是生命的延续，而是**以永生之名进行的自我消灭**，它用一个复制品替换了原本。 本文首先区分三种常被混为一谈的操作：**非破坏性复制**、**破坏性扫描—摧毁**、**裂变**。非破坏性复制摧毁的是**唯一性**而非原我，后两者则杀死原我。这个区分之所以要紧，是因为"多份共存"通常被当作同一个谜题，而三种情形的判决并不相同。 接着是两组论证。其一，**信息同一不是数的同一**：同卵双胞胎共享全部基因，克隆体的核 DNA...
Open Science Framework July 17, 2026 Stephen P. Lewis
Objective: The objective of this narrative review is to understand what forms of spirituality screening and spiritual support are available to individuals with serious or life-threating illness involved in psychedelic-assisted therapies. Introduction: In addition to physical pain related to disease and treatment processes, people encountering serious illness frequently experience psychological...
Open Science Framework July 9, 2026 Raul Edison Luna Lazo, Nicole Milagritos Cardoso Azorza, Jatziri Yanina Vilca Yanac et al.
Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition characterized by intrusive thoughts and repetitive behaviors that cause distress and functional impairment worldwide. Although selective serotonin reuptake inhibitors and cognitive behavioral therapy are first-line treatments, a considerable proportion of patients show an insufficient response, supporting the need for...
Open Science Framework July 5, 2026 Dante Sebastián Galván Rial, Panagiotis Fotiadis, Marina Dauphin et al.
Understanding how different states of consciousness arise from brain activity remains a central challenge in consciousness science. Theoretical and empirical work has increasingly linked conscious states to the large-scale organization and dynamical complexity of brain activity, using measures ranging from network integration and graph-theoretical properties to signal diversity, perturbational...
Open Science Framework 2026 Annemarie van der Meij, Sotiris Poyiadis, Andrea Cipriani et al.
This preregistration documents an update and extension of a meta-analysis of ketamine and esketamine for adults with treatment-resistant major depressive disorder (TRD). The project is nested within an existing network meta-analysis for TRD (NMA-TRD) project, which has already been fully specified and registered: • Muit et al., BMJ Open 2022 – protocol for a systematic review and network...
Open Science Framework 2026 Christina Chwyl, M. Kati Lear, Sunjeev K. Kamboj et al.
Self-compassion is theorized to play a central role in promoting mental health and wellbeing, including for individuals with social anxiety disorder (SAD). One proposed mechanism of MDMA-assisted therapy (MDMA-AT) for SAD is the cultivation of self-compassion. Across five aims, we will characterize self-compassion experiences during MDMA-AT and evaluate its role as a potential mechanism of...
Open Science Framework November 6, 2025 Michiel van Elk
We investigate how the dose of psilocybin truffles and participant characteristics (trait absorption and expectations) influence subjective experiences and neurophysiological outcomes in a naturalistic field setting.The aim is to replicate observed effects of psilocybin from lab-based and clinical studies in a field / naturalistic setting.
Open Science Framework October 20, 2025 Natalia Fernandez‐Vinson, Roger Atkins, Marcus J. Glennon et al.
This study examines the existence and mechanistic underpinnings of lasting neural, cognitive, and behavioural plasticity in response to N-N-dimethyltryptamine (DMT) in a hazardous drinking population. It combines behavioural, neuroimaging, ecological momentary and qualitative data to gain a holistic understanding of potential mechanisms of therapeutic change following DMT. Primarily, we test...
Open Science Framework 2025 Federico Cavanna, Enzo Tagliazucchi
This project investigates the acute effects of psilocybin on probabilistic reinforcement learning in healthy adults. Using a double blind, randomized, within-subject, placebo-controlled design, we will analyze behavioral data and Event-Related Potentials (ERPs) from EEG recordings to understand how psychedelics modulate neural mechanisms of reward processing and decision-making.
Open Science Framework 2025 Aimee Freeburn, Alene Sze Jing Yong, Simon Bell
This rapid review aims to synthesise recommendations and statements from international clinical guidelines, consensus statements, and position statements regarding the medical use of psilocybin-assisted psychotherapy (PAP) in adults living with depression.
Open Science Framework 2025 Mackenzie Hancock, Shambhu Prasad Adhikari, Nicole Getz
This scoping review examines the emerging evidence for psilocybin-assisted therapy (PAP) in treating trauma-related disorders such as posttraumatic stress disorder (PTSD), depression, and persistent post-concussion symptoms (PPCS), with specific implications for intimate partner violence (IPV)-related brain injury and PTSD. Guided by PRISMA-ScR methodology, we systematically searched Medline,...