Mindfulness-based interventions have demonstrated benefits for emotional regulation, psychological resilience, and well-being, yet the structural mechanisms through which mindfulness produces sustained transformation remain insufficiently articulated. Existing explanations—attention regulation, body awareness, decentring, emotion regulation, neuroplasticity—are typically presented as parallel...
Abstract Objectives Mindfulness-based digital interventions have shown promise for improving health outcomes. The Mindfulness Coach (MC) mobile app was found to improve posttraumatic stress disorder (PTSD) and depression symptoms in a pilot randomized controlled trial (RCT). The current secondary analyses expand on these findings by assessing changes in mindfulness-related processes targeted by...
Depersonalization (DP) and Derealization (DR) may be detected in healthy individuals often under condition of stress, fatigue or drug abuse, and has been described in a number of psychiatric (panic disorder, major depression, posttraumatic stress disorder, schizophrenia, bipolar disorder) and neurological conditions (migraine, epilepsy, etc.) [1-4].
medRxivJuly 10, 2026Daniel Copeland, Naoise Mac Giollabhui, Louisa G Sylvia et al.
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Background: Despite growing evidence that lifestyle interventions reduce depressive symptoms, the psychological mechanisms underlying these effects remain poorly understood. This study examined whether mindfulness and rumination mediate the antidepressant effects of heated yoga (HY), a multicomponent intervention combining physical activity, attentional training, and thermoregulatory stress....
Background: There are currently more than 750 million women worldwide aged 40-60 years, the age during which the majority undergo menopausal transition. This period is often marked by challenging symptoms that affect physical and mental health, productivity, and quality of life, sometimes becoming severe enough to compromise personal and professional relationships. A substantial proportion of...
A resurgent therapeutic frontier, the contemporary renaissance in psychedelic science has accelerated investigation of classic serotonergic psychedelics (psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline), empathogenic entactogenic agents (3,4-methylenedioxymethamphetamine (MDMA)), and glutamatergic dissociatives (ketamine) as adjuncts to psychotherapy. While...
Objective Students in higher education (HE) increasingly experience challenging concerns from stress to anxiety and depression. Mindfulness-based interventions (MBIs) became a popular strategy to help students cope with these. This systematic review aimed to evaluate the efficacy, scalability and sustainability of various MBIs implemented in HE to identify strengths, limitations and possible...
High Resolution Image Download MS PowerPoint Slide The psychedelic therapeutics field continues to evolve beyond classical hallucinogens toward integrated treatment platforms that combine optimized pharmacology, drug delivery, and clinical implementation. Recent patent applications disclose selective 5-HT2A receptor activators, precision aerosol delivery technologies for psychedelic compounds,...
European Journal of PharmacologyJuly 10, 2026Amanda Gollo Bertollo, Vinicius Alexandre Wippel, Maiqueli Eduarda Dama Mingoti et al.
Major Depressive Disorder (MDD) is a debilitating mental health condition that significantly impacts quality of life. Despite available pharmacological treatments, response rates remain suboptimal, with a considerable number of patients experiencing treatment-resistant depression (TRD). Indeed, classical antidepressants, primarily targeting monoaminergic systems, exhibit a therapeutic delay due...
Dissociative experiences are highly common in borderline personality disorder (BPD) and have been associated with childhood abuse and neglect. Only few studies so far differentiated between specific forms of psychoform and somatoform dissociation, childhood trauma, and BPD domains. This study aimed to simultaneously investigate how psychoform dissociation (depersonalization derealization,...