Background Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused on perineuronal nets (PNNs), an extracellular matrix structure that surrounds fast-spiking parvalbumin-positive interneurons and regulates...
The prevalence of nightmares appears to be highly variable in this current literature on nightmares, ranging from low in healthy populations (6% to 11%), to slightly higher in those with medical problems (12% to 13%), significantly higher in individuals with neurological conditions (24% to 30%) and again significantly higher in those with psychiatric diagnoses (27% to 62%). Medical...
BACKGROUND Altered experiences of space and time are core features of schizophrenia spectrum disorders (SSD) and mood disorders (MOD). In this study, we investigated whether patients with SSD and MOD exhibit shared or distinct patterns of subjective spatiotemporal experience. METHODS We examined 62 ICD-11 patients (33 SSD, 29 MOD) using the Scale for Space and Time Experience in Psychosis...
Background: Breast cancer is a global health issue that not only affects physical health but also causes psychological distress and a decline in quality of life. Various non-pharmacological interventions have been developed to help patients adapt to the disease, one of which is mindfulness. Evidence regarding the effectiveness of mindfulness in breast cancer patients remains inconsistent,...
Since the introduction of disulfiram in 1951 (the first ever Food and Drug Administration (FDA)-approved medication for substance use disorders (SUDs)) (1), only seven other individual medications have been approved for the treatment of SUDs. While the repurpose of medications and different formulations increase the total number of FDA-approved medicines (Table 1 and(2)), the arsenal of...
Aim As students are vulnerable to mental disorders, interventions for promoting mental health and well-being are urgently needed. Third-wave behavioural therapy programmes (e.g., ACT and MSC) have shown promising results in addressing these issues. The online health promotion programme SAM was developed in a multistage process using a participatory design with students at the University of...
To evaluate the clinical efficacy of body scan mindfulness training as an intervention for patients with burning mouth syndrome (BMS). This randomized, controlled, single-blind clinical trial enrolled patients with BMS who met the inclusion and exclusion criteria. Participants were assigned to a control group or an intervention group using a random number table. The control group received...
Adolescents and emerging adults are still learning how to manage their emotions, and for most young people worldwide, faith and spiritual life are part of how that learning happens. Emotional regulation (ER) is usually defined as the set of processes people use to influence which emotions they have, when they have them, and how those emotions get expressed. Spirituality and religiosity (R/S)...
Abstract Background: Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients' quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescents remain under-explored. Methods: In this study, a prospective, randomized, double-blind, controlled trial was...
Various programs focus on psychological well-being associated with spiritual and personal growth, but empirical studies assessing the evidence are scarce. The objective of this pilot is to examine the results of the first year of the extensive Orientation on Being (OB) program in the Netherlands. A prospective and quasi-experimental design was used in which changes in various indices of...