This study investigated the impact that meditation has on Fordyce's (1977, 1983) Personal Happiness Enhancement Program (PHEP). Experimental subjects were divided into two groups, both of which received instruction on the PHEP. Subjects in one experimental group were taught a meditation exercise in addition to the PHEP. A control group received no instruction. The Happiness Measure, Psychap...
The cognitive processes which mediate self-consciousness are unknown. although Morin and others have suggested that inner speech may mediate self-consciousness. We developed a questionnaire which measures the extent to which one talks to oneself about oneself. As expected, the correlation between inner speech and self-consciousness was significant. A German version of the 1979 self-deception...
Fibromyalgia is a chronic illness characterized by widespread pain, fatigue, sleep disturbance, and resistance to treatment. The purpose of this study was to evaluate the effectiveness of a meditation-based stress reduction program on fibromyalgia. Seventy-seven patients meeting the 1990 criteria of the American College of Rheumatology for fibromyalgia took part in a 10-week group outpatient...
Impulsive behaviours affect patients with major depressive disorder (MDD) and bipolar disorder (BP), increasing suicide risk and mood instability. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been reported to promote fast-acting antidepressive and antisuicidal effects. Magnesium administered contemporarily with low-dose NMDA antagonists has been shown to cause a reduction...
Background: Since the Food and Drug Administration designated lysergic acid diethylamide (LSD) as a “breakthrough” treatment for generalized anxiety disorder, accumulating randomized clinical trials (RCTs) evaluating LSD’s anxiolytic effects have also reported improved depression symptoms. Evaluating the safety and efficacy of LSD in treating depression symptoms is warranted. Methods:...
Research SquareOctober 29, 2026Jiaojian Wang, Jin Chen, Wenjie Sun et al.
preprint
Abstract Psilocybin holds strong therapeutic promise for treating major depressive disorder. However, the cellular and molecular substrates underlying its action have not been fully elucidated, especially in the primate brain. We combined multimodal MRI, magnetic resonance spectroscopy (MRS), cerebrospinal fluid (CSF) proteomics and metabolomics, and single-nucleus RNA sequencing (snRNA-seq) to...
Background: Psychosis-like experiences (PLEs) are subclinical phenomena situated along the psychosis continuum whose clinical significance depends not only on their occurrence but also on the distress they elicit. Phenomenological frameworks suggest that disturbances in self-experience may constitute a core dimension of vulnerability to PLEs. However, the relationship between social...
Revista FocoOctober 28, 2026Rhanna Mickelly Moreno Do Nascimento, Emily Lobo Ferreira da Silva, Vitor Duarte Falci et al.
A depressão maior resistente ao tratamento configura um importante desafio clínico e de saúde pública, caracterizado pela ausência de resposta satisfatória a esquemas terapêuticos convencionais. Diante das limitações dos antidepressivos tradicionais, a psilocibina tem sido investigada como alternativa terapêutica promissora, especialmente quando administrada em ambiente clínico controlado e...
Journal of FungiOctober 28, 2026Sen Yao, Yuanyuan Liu, Weiwei Xia et al.
Psilocybin has demonstrated efficacy in the treatment of mental health conditions, including anxiety and depression. It is evident that G. dilepis possesses the capacity to produce psilocybin. Therefore, conducting in-depth research into this species will contribute to the understanding of the biosynthetic mechanisms of psilocybin and provide a more comprehensive insight into its biosynthesis....
Frontiers in PsychologyOctober 27, 2026Nasiru Mohammed Abdullahi, Rashid Menhas, Patience Osose Nasir et al.
Background: Clinical research on psychedelic-assisted therapy (PAT) has expanded substantially in recent years, particularly for post-traumatic stress disorder (PTSD) and depressive disorders. Contemporary studies have generally evaluated psychedelic administration within controlled therapeutic settings that include psychological support, preparation, and integration. However, variability in...