Preprints.org
October 19, 2026
Maxwell Jackson Harrell
preprint
The transmission of consciousness through a chemical synapses is an under-specified probable occurrence. Chemical transmission is essential for neuronal propagation and neural propagation is essential within many existing measurements of consciousness. The development and plasticity of consciousness throughout an animal's lifetime requires grounded chemical distinctions, executive and...
Diálogos Interdisciplinares em Psiquiatria e Saúde Mental
October 19, 2026
Letícia Macedo Pinto, Lucas Macedo Pinto, Joel Porfírio Pinto
Introduction: Obsessive-Compulsive Disorder (OCD) presents approximately 20% of cases refractory to conventional treatments, driving the investigation of pathophysiological pathways, including the glutamatergic hypothesis. In this context, ketamine emerges as a potential intervention. This study reviewed the literature on ketamine use in OCD, focusing on efficacy, mechanisms, and safety....
Cancer Epidemiology Biomarkers & Prevention
October 18, 2026
Brooke Bethune, Ranjita Poudel, Marilyn Horta et al.
Abstract Background: African American cancer caregivers (AACCs) disproportionately assume caregiving responsibilities, often serving as sole unpaid caregivers to provide extensive support to their loved one. AACCs face financial strain, unemployment, psychological distress, sleep disturbance, medical mistrust, mental health stigma, and caregiving expectations shaped by family and cultural...
Journal of Happytalism and Fundamental Peace
October 18, 2026
Luis Miguel Gallardo
Background Psychedelic medicine is approaching regulatory approval, and suggestion alone can now occasion mystical-type experiences in the laboratory. Yet the field still names altered states after their triggers, and nobody can yet show whether the state itself, rather than its context, is what heals. Objective This review reads the evidence presented at the 2026 Annual Conference of the...
Drug Design, Development and Therapy
October 17, 2026
Zhaoying Zhong, Baozhen Liao, Donglan Peng et al.
Pain, depressive symptoms, and sleep disruption frequently overlap during the peripartum period, although their relationships are associative rather than established as causal. Esketamine, an N-methyl-D-aspartate receptor antagonist, has attracted interest as a peripartum intervention with potential effects on pain, mood, and sleep. This narrative review evaluates the clinical and mechanistic...
Psychopharmacology
October 17, 2026
Andreas Krabbe, Lena Lindström, Pilleriin Sikka et al.
Combining meditation with psychoactive substances is often assumed to be a niche practice centred on classic psychedelics. We sought to broaden this narrative in two cross-sectional studies. Study 1 used a broad naturalistic sample (N = 1,391) to examine the prevalence of substance use, meditation, and their simultaneous combination, as well as associations with subjective happiness. Study 2...
BMC Psychiatry
October 16, 2026
Morfeas Koumas, Markos Apostolakis, Evanthia Bella et al.
Abstract Background Opioid use disorder (OUD) is a chronic relapsing condition associated with substantial mortality. Although medications for opioid use disorder (MOUD) can be effective in reducing opioid use and improving treatment outcomes, relapse to drug use remains common, highlighting the need for adjunctive interventions that address relapse-relevant symptoms not fully targeted by MOUD...
L'Encephale
October 16, 2026
Anne Buot, Jean-Del Burdairon, Luc Mallet et al.
The use of psychedelic substances such as LSD, psilocybin, and dimethyltryptamine is currently being re-evaluated for their therapeutic potential in psychiatry. While international clinical research had started in the 2010s, France only initiated its first psychedelic trials in 2024. This study aimed to explore the knowledge, perceptions, and attitudes of French mental health professionals...
Otago University Research Archive
October 15, 2026
Shirley Katharine Anne Harris
Background: The psychological and physiological impacts of chronic obstructive pulmonary disease (COPD) may exacerbate the anxiety-breathlessness cycle, reduce self-efficacy and impede self-management. The integrative literature included in this current study, highlighted evidence to suggest mindfulness-based interventions may increase self-awareness and self-efficacy and reduce symptom burden....
International Journal of Molecular Sciences
October 15, 2026
Ana Zivanovic, Iva Lukic, Emilija Glavonic et al.
Ketamine produces rapid antidepressant-like effects across a range of subanesthetic doses, yet how dose shapes behavioral efficacy and region-specific molecular signaling following adolescent chronic unpredictable stress (CUS) is not well understood. Here, we examined the behavioral and molecular consequences of two subanesthetic ketamine doses in adult mice with depression-like behavior...