Harvard Review of Psychiatry
August 1, 2010
Carlos A. Zarate, Rodrigo Machado‐Vieira, Ioline D. Henter et al.
226 citations
Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide. Existing antidepressants and mood stabilizers used to treat these disorders are insufficient for many. Patients continue to have low remission rates, delayed onset of action, residual subsyndromal symptoms, and relapses. New therapeutic...
Pharmaceuticals
January 6, 2010
Rodrigo Machado‐Vieira, Jacqueline Baumann, Cristina Wheeler-Castillo et al.
Currently available antidepressants used to treat major depressive disorder (MDD) unfortunately often take weeks to months to achieve their full effects, commonly resulting in considerable morbidity and increased risk for suicidal behavior. Our lack of understanding of the precise cellular underpinnings of this illness and of the mechanism of action of existing effective pharmacological...
Psychology, Health & Medicine
October 1, 2009
Erin L Olivo, Brooke Dodson-Lavelle, Anava A Wren et al.
Feasibility and effectiveness of a brief meditation-based stress management intervention for patients diagnosed with or at risk for coronary heart disease: a pilot study.
The Journal of Clinical Psychiatry
September 8, 2009
Rodrigo Machado‐Vieira, Peixiong Yuan, Nancy E. Brutsché et al.
154 citations
OBJECTIVE: A model has been proposed to explain the pathophysiology of mood disorders based on decreased neurotrophin levels during mood episodes; treatment with antidepressants and mood stabilizers is associated with clinical improvement. This study investigated whether changes in brain-derived neurotrophic factor (BDNF) levels are associated with the initial antidepressant effects of...
Applied Psychophysiology and Biofeedback
August 6, 2009
Sat Bir S Khalsa, Stephanie M Shorter, Stephen Cope et al.
Yoga and meditation can alleviate stress, anxiety, mood disturbance, and musculoskeletal problems, and can enhance cognitive and physical performance. Professional musicians experience high levels of stress, performance anxiety, and debilitating performance-related musculoskeletal disorders (PRMDs). The goal of this controlled study was to evaluate the benefits of yoga and meditation for...
Journal of Affective Disorders
July 24, 2009
Patrick Mcnamara, Sanford Auerbach, Patricia Johnson et al.
Introduction: We tested the hypothesis that REM sleep contributes to core features of cognitive dysfunction of anxious depression including negative self-appraisals, biased memory processing and unpleasant dream content. Methods: After a habituation night in a sleep lab, a convenience sample of 35 healthy college students and 20 depressed/anxious students were awakened 10 min into a REM sleep...
Psychopathology
May 16, 2009
Erika Szily, Szabolcs Kéri
Background: Help-seeking young people often display depressive symptoms. In some patients, these symptoms may co-exist with clinically high-risk mental states for psychosis. The aim of this study was to determine differences in subjective experience and social perception in young depressed patients with and without psychosis risk. Methods: Participants were 68 young persons with major...
Frontiers in Systems Neuroscience
2009
Michael C. Quirk, Dara L Sosulski, Claudia E Feierstein et al.
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons...
Psychological Reports
October 1, 2008
Marco Zanasi, Martina Pecorella, Carlo Chiaramonte et al.
This work evaluated the structure of dreams in depressed patients. The verbal reports of dreams of 100 depressed patients were compared with 251 dreams of a control group. In accordance with the Jungian thought, which views dreams as texts, dream reports were assessed using textual analysis processing techniques. Significant differences were found in parameter values, as well as in the role of...
The Journal of Nervous and Mental Disease
August 1, 2008
Thomas J Csordas, Michael J Storck, Milton Strauss
In contemporary Navajo society, traditional Navajo ceremonies, Native American Church prayer meetings, and Navajo Christian faith healing are all highly sought-after resources in the everyday pursuit of health and well-being. What is the nature of affliction among patients who turn to such forms of religious healing? Are these patients typically afflicted with psychiatric disorder? In this...