Background Recent work suggests that psilocybin, a hallucinogenic 5-HT 2A R agonist with rapid and long-lasting anti-depressant actions, facilitates fear extinction retention in adult rodents. However, psilocybin’s effects on adolescent fear extinction are unknown. Further, chronic stress in adolescence predisposes individuals to developing psychopathologies such as anxiety and fear-related...
To evaluate the effect of a structured 12-week yogic intervention comprising yogic asanas, pranayama and guided meditation on stress, anxiety and sleep pattern among adult male cardiac and diabetic patients. Sixty male patients aged 45-70 years (30 cardiac and 30 diabetic) participated; within each clinical category, 15 were assigned to an experimental group and 15 to a control group. The...
Clinical TherapeuticsSeptember 2026Jonathon K. Lisano, Luiza Rosa, Greg Giordano et al.
Emerging research indicates that the use of cannabis products, particularly those higher in cannabidiol (CBD), may be anxiolytic. Physical activity is another modality observed to have anxiolytic effects. Despite evidence of cannabis and physical activity being paired together, there is limited research on the possible synergistic effects of physical activity and cannabis use on reductions in...
Psychopharmacology, once propelled by a series of serendipitous mid-20th-century discoveries, has matured into a field defined by mechanistic diversity, translational neuroscience, and an expanding array of circuit-based interventions. Despite more than 100 approved psychiatric drugs, remission rates for major depressive disorder and other serious mental disorders remain modest, underscoring...
Mindful yoga for depression and possible mediating processes This review article describes a study on the added value of mindful yoga in the treatment of depression. Although existing treatments such as cognitive behavioral therapy can help with depression, a large proportion of people with depression do not recover or do not recover sufficiently. Therefore, it is important to develop new...
The dose-response profile of racemic ketamine in internalizing disorders is poorly characterized. This was a secondary analysis of outcome responses in patients with treatment-resistant depression, post-traumatic stress disorder, generalized and/or social anxiety, or obsessive-compulsive disorder. For each disorder, they received single intramuscular doses of racemic ketamine (0.5 and 1.0...
Purpose: Postoperative anxiety is common in surgical patients and may impair recovery, especially in the patients with preoperative anxiety. However, effective strategies for treating postoperative anxiety remain limited. We hypothesized that esketamine could reduce postoperative anxiety in patients with preoperative anxiety undergoing major abdominal tumor surgery. Patients and Methods: 180...
Abstract Background Studies and the S3 practice guidelines in psychiatry and psychotherapy show that health-promoting measures are highly relevant in the treatment of mental illness. Current psychiatric care research still shows ambivalent findings regarding the effects of specific diets on psychopathogenic symptoms. In particular, the quality of nutrition and different effects in a...
An Executive Order signed in April 2026 directed US federal agencies to expedite development and review pathways for psychedelic and psychedelic-adjacent (such as ibogaine) therapies. The FDA issued Commissioner's National Priority Vouchers to psilocybin developers, and cleared the investigational new drug (IND) application for noribogaine hydrochloride for alcohol use disorder. These...