Journal of Psychiatric Practice
May 1, 2026
Mohammad Asif Sheikh
Objectives: Perceived stress is a significant concern among health care professionals, with potential consequences for mental health and clinical performance. This study examined associations between dispositional mindfulness and perceived stress among Indian physicians working in psychiatric and nonpsychiatric specializations within hierarchical systems with limited institutional support....
Journal of Psychiatric Practice
September 1, 2025
Matteo Carminati, Mattia Tondello, Barbara Barbini et al.
2 citations
Treatment-resistant depression (TRD) remains a relevant issue in psychiatric practice, driving the exploration of innovative therapeutic alternatives. Ketamine and its enantiomer, esketamine, are emerging as treatments known for their effectiveness as rapid-acting antidepressants. Although previous comparative studies have highlighted some differences in their effects, they did not concurrently...
Journal of Psychiatric Practice
May 1, 2025
Marc J. Weintraub, David J. Miklowitz, Jessica K Jeffrey
We present divergent experiences of 2 patients who participated in a clinical trial of psilocybin-assisted cognitive behavioral therapy for major depressive disorder. Both patients participated in an open trial involving 2 drug administration sessions separated by one month (10 and 25 mg, respectively) along with 12 sessions of cognitive behavioral therapy. The first of the 2 patients had...
Journal of Psychiatric Practice
May 1, 2025
Amir Garakani
Nitrous oxide (N2O), an anesthetic gas used for dental procedures, has recently become increasingly recognized as a potential drug of misuse and abuse, with an increasing number of case studies reporting serious adverse effects, including megaloblastic anemia, myelopathy, neuropathy, subacute combined degeneration, psychosis, and even death. There is also growing research support for the use of...
Journal of Psychiatric Practice
May 1, 2024
Aniruddha Deka, Emmanuel Joseph, Neha Sharma et al.
3 citations
Serotonin (5-HT) syndrome (SS) consists of changes in mental status as well as autonomic and neuromuscular changes. Though not well understood, serotonergic pathways have been implicated in the mechanism of action of electroconvulsive therapy (ECT). Ketamine has been used as an induction agent in ECT and as therapy for treatment-resistant depression. Utilizing a case report and literature...
Journal of Psychiatric Practice
March 1, 2024
Brian S. Barnett
5 citations
For more than 2 decades, intravenous ketamine has been demonstrated to have rapid antidepressant effects. However, access to this generic drug is limited due to insurers claiming it is "experimental" because ketamine does not have a Food and Drug Administration indication for depression. In contrast, intranasal esketamine, an enantiomer of ketamine, is approved by the Food and Drug...
Journal of Psychiatric Practice
March 1, 2024
Sheldon H. Preskorn
This column focuses on the status of intravenous racemic ketamine for the treatment of patients suffering from a form of major depressive disorder that does not respond to trials of currently available biogenic amine antidepressants. To provide context, the column reviews the 3 pivotal elements of the usual Food and Drug Administration (FDA) drug approval process: (1) the unmet medical need...
Journal of Psychiatric Practice
September 1, 2023
Amir Garakani, Jeanne L Alexander, Calvin R Sumner et al.
6 citations
There has been a burgeoning interest in psychedelics among the public, state legislatures, psychiatrists and other clinical providers, and within the research community. Increasing numbers of studies evaluating psychedelics for depression, anxiety, posttraumatic stress disorder, and substance use disorders have been conducted or are underway. While discussing psychedelics in general, the focus...
Journal of Psychiatric Practice
November 1, 2021
Amir Garakani
Treatment-resistant depression (TRD) may be responsive to interventions beyond antidepressants including brain stimulation such as electroconvulsive therapy (ECT) or to ketamine or esketamine, the latter of which is approved for TRD in an intranasal form. The 3 cases presented in this issue deal with an array of clinical considerations in treating patients with TRD, including the use of ECT in...
Journal of Psychiatric Practice
March 1, 2021
Sheldon H. Preskorn
3 citations
This column reviews the development of intranasal esketamine with particular emphasis on the consistency of the clinical trial results. In the process, it illustrates methodological issues important in the approval process by an agency such as the United States Food and Drug Administration. Topics covered include the importance of study design, the nature of the comparator, and the prespecified...
Journal of Psychiatric Practice
September 1, 2019
Matthew J Begola, Jason E Schillerstrom
20 citations
The exploration of possible therapeutic benefits of hallucinogenic substances has undergone a revitalization in the past decade. This literature review investigated the published literature regarding the psychotherapeutic uses of hallucinogens in psychiatric disorders. The results showed that a variety of substances have been evaluated in the treatment of psychiatric disorders, including...
Journal of Psychiatric Practice
July 1, 2018
Lai Fong Chan, Choon Leng Eu, Shean Yih Soh et al.
18 citations
Ketamine has shown effectiveness as a rapid-acting antidepressant with antisuicidal effects in terms of reduction of suicidal ideation in the short term. However, the evidence for long-term maintenance ketamine therapy for treatment-resistant depression (TRD) and suicidal behavior is limited. This case series (N=13) highlights the role of adjunctive serial maintenance ketamine infusions in...
Journal of Psychiatric Practice
November 1, 2015
Ajay K Parsaik, Balwinder Singh, Darrow Khosh-Chashm et al.
42 citations
Retracted
To consolidate the evidence from the literature to evaluate the role of ketamine in the treatment of bipolar depression. Major databases, including MEDLINE, EMBASE, Cochrane, and Scopus, were searched through October 2014, for studies reporting the role of ketamine in the treatment of bipolar depression. Only randomized controlled trials were included in the meta-analysis. We calculated...
Journal of Psychiatric Practice
July 1, 2012
William R. Marchand
309 citations
Mindfulness has been described as a practice of learning to focus attention on moment-bymoment experience with an attitude of curiosity, openness, and acceptance. Mindfulness practices have become increasingly popular as complementary therapeutic strategies for a variety of medical and psychiatric conditions. This paper provides an overview of three mindfulness interventions that have...
Journal of Psychiatric Practice
November 1, 2011
Jonathan P. Stange, Lori Eisner, Britta K. Hölzel et al.
83 citations
Bipolar disorder is associated with impairments in cognition, including difficulties in executive functioning, even when patients are euthymic (neither depressed nor manic). The purpose of this study was to assess changes in self-reported cognitive functioning in patients with bipolar disorder who participated in an open pilot trial of mindfulness-based cognitive therapy (MBCT). Following MBCT,...
Journal of Psychiatric Practice
May 1, 2011
Norman A Clemens
The author draws upon the experience of singing Beethoven's Missa Solemnis to explore the feeling states aroused by religious choral music, especially the Mass. He relates them to working with patients in psychotherapy around issues of dying, death, the "oceanic feeling" of the religious experience, the human quest for knowledge, and yearning for an eternal, intelligent, and all-knowing entity...