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Xiaochen Zhao

2 papers in the library · 136 citations · publishing 2012-2026

Papers

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Worldliness and causal binding in intelligent machines: a Heideggerian response to Dreyfus

Humanities and Social Sciences Communications July 20, 2026 Xiaochen Zhao

Generative language models seem to refute Hubert Dreyfus’s verdict that AI can never match human “knowing-how.” Re-reading Dreyfus through Heidegger, this paper argues that the decisive divide is not skilled coping versus rules, but correlational patterning versus teleological causation. The latter is termed causal-intentional binding —Dasein’s future-oriented act of opening meanings for which...

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

British Journal of Clinical Pharmacology February 1, 2012 Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel et al. 136 citations

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • (R,S)‐ketamine is a phencyclidine derivative that was initially developed as an anaesthetic agent and which is currently being studied in the treatment of pain and depression. After administration, the drug is extensively N‐demethylated to (R,S)‐norketamine. The pharmacokinetics of ketamine and norketamine have been extensively studied in volunteers...