bioRxiv Preprint Server
December 9, 2025
Tomas Berjaga-Buisan, Juan Manuel Monti, Martina Cortada et al.
preprint
The quest for reliable and objective measures of consciousness is critical in basic and clinical neuroscience. Across species, the Perturbational Complexity Index (PCI) has emerged as a robust empirical marker by directly perturbing the brain, yet its underlying principles of physics are not fully understood. Here, we bridge this gap by introducing a non-invasive framework based on generative...
PLoS Biology
October 1, 2025
Michele Angelo Colombo, Jacopo Favaro, Ezequiel Mikulan et al.
7 citations
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy, which entails disconnecting a significant portion of the cortex, potentially encompassing an entire hemisphere, from its cortical and subcortical connections. While this intervention prevents the spread of seizures, it raises important questions. Given the complete isolation from sensory-motor pathways, it remains...
Current biology : CB
June 9, 2025
Davide Albertini, Maria Del Vecchio, Ivana Sartori et al.
9 citations
Distilling the neural correlates of consciousness (NCCs) in humans is challenging due to limitations in the spatiotemporal resolution of recording techniques and confounds related to pre- and post-perceptual processes. In this study, we leveraged the detailed insights provided by human intracortical recordings to elucidate how somatosensory responses to simple tactile stimuli vary across...
Eur J Neurosci
November 18, 2024
Athina Tzovara, Thomas Andrillon, Katrin H. Preller et al.
Understanding what makes us conscious is one of the major frontiers of science. There are two main approaches to the mystery of consciousness. The first regards conscious states (i.e., being conscious) and how certain global states (e.g., of arousal) can support the formation of any conscious experience. Insights into the neural processes underlying the capacity for consciousness stem from...
iScience
May 19, 2023
Andres Ort, John W Smallridge, Simone Sarasso et al.
47 citations
Exploring the neurobiology of the profound changes in consciousness induced by classical psychedelic drugs may require novel neuroimaging methods. Serotonergic psychedelic drugs such as psilocybin produce states of increased sensory-emotional awareness and arousal, accompanied by increased spontaneous electroencephalographic (EEG) signal diversity. By directly stimulating cortical tissue, the...
Neuroscience of Consciousness
2021
Simone Sarasso, Adenauer G. Casali, Silvia Casarotto et al.
183 citations
Abstract Over the last years, a surge of empirical studies converged on complexity-related measures as reliable markers of consciousness across many different conditions, such as sleep, anesthesia, hallucinatory states, coma, and related disorders. Most of these measures were independently proposed by researchers endorsing disparate frameworks and employing different methods and techniques....
Neuroimage
January 11, 2019
Michele A. Colombo, Martino Napolitani, Melanie Boly et al.
359 citations
Despite the absence of responsiveness during anesthesia, conscious experience may persist. However, reliable, easily acquirable and interpretable neurophysiological markers of the presence of consciousness in unresponsive states are still missing. A promising marker is based on the decay-rate of the power spectral density (PSD) of the resting EEG. We acquired resting electroencephalogram (EEG)...
Neuroscience of Consciousness
January 27, 2017
Michael Schartner, Andrea Pigorini, Steve A. Gibbs et al.
158 citations
Key to understanding the neuronal basis of consciousness is the characterization of the neural signatures of changes in level of consciousness during sleep. Here we analysed three measures of dynamical complexity on spontaneous depth electrode recordings from 10 epilepsy patients during wakeful rest (WR) and different stages of sleep: (i) Lempel-Ziv complexity, which is derived from how...
Annals of Neurology
September 22, 2016
Silvia Casarotto, Angela Comanducci, Mario Rosanova et al.
504 citations
OBJECTIVE: Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness-the Perturbational Complexity Index (PCI)-in a benchmark population who could confirm the...
Clinical EEG and Neuroscience
2014
Simone Sarasso, Mario Rosanova, Adenauer G. Casali et al.
164 citations
We normally assess another individual's level of consciousness based on her or his ability to interact with the surrounding environment and communicate. Usually, if we observe purposeful behavior, appropriate responses to sensory inputs, and, above all, appropriate answers to questions, we can be reasonably sure that the person is conscious. However, we know that consciousness can be entirely...
Science Translational Medicine
August 14, 2013
Adenauer G. Casali, Olivia Gosseries, Mario Rosanova et al.
1,299 citations
One challenging aspect of the clinical assessment of brain-injured, unresponsive patients is the lack of an objective measure of consciousness that is independent of the subject's ability to interact with the external environment. Theoretical considerations suggest that consciousness depends on the brain's ability to support complex activity patterns that are, at once, distributed among...
The International Journal of Neuropsychopharmacology
June 7, 2012
Wallace C. Duncan, Simone Sarasso, Fabio Ferrarelli et al.
253 citations
The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD). In rats, ketamine selectively increased electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (REM) sleep and altered central brain-derived neurotrophic factor (BDNF) expression. Taken together, these findings suggest...