Background Recent research has increasingly focused on the potential role of white ginseng (Panax ginseng Meyer, PGC) in alleviating psychological conditions. This study aims to evaluate the efficacy and safety of PGC in reducing stress and tension over a 12-week period, employing a randomized, double-blind, placebo-controlled trial design. Methods A total of 86 participants reporting...
The default mode network (DMN) has been linked to self-reflection and theory of mind, suggesting that it facilitates understanding others by reflecting on ourselves. This raises the question of whether shared (synchronized) DMN responses are associated with mutual understanding. The current paper reviews studies on DMN synchronization during shared understanding of external events, regarding...
PLoS BiologyAugust 1, 2025A. Rezaei, Corson N. Areshenkoff, Daniel J. Gale et al.
An often-desired feature of motor learning is that it generalizes to untrained scenarios. Yet, how this is supported by brain activity remains poorly understood. Here we show, using human functional MRI and a sensorimotor adaptation task involving the transfer of learning from the trained to untrained hand, that the transfer phase of adaptation re-instantiates a highly similar large-scale...
EJNMMI ResearchJuly 11, 2025Chun-Qing Zhou, Xueying Wang, Mei-Chao Men et al.
This study delineates brain metabolic signatures underlying neuroendocrine-psychosocial interactions in Kallmann syndrome (KS), a rare genetic disorder characterized by congenital hypogonadism and anosmia. In this prospective case-control study, 30 KS patients and 30 matched healthy controls (HCs) underwent brain [18F]FDG PET scans, sex hormone assays, and standardized neuropsychological...
IntroductionAlthough a number of neuroimaging studies on problematic internet use (PIU) have been conducted, few studies on non-problematic internet use (non-PIU) are available; therefore, the influences of non-PIU on brain function are unclear. Resting-state functional connectivity (rsFC) could be an appropriate tool to investigate subclinical samples, such as non-PIU, to capture the...
Internet gaming disorder (IGD) is a pervasive global mental health issue, and finding effective treatments for the disorder has been challenging. Mindfulness meditation (MM), recognized for its holistic approach that involves integrating mental and physical facets, holds promise for addressing the multifaceted nature of addiction. Nevertheless, the effect of MM on IGD and its associated neural...
The default mode network (DMN) exhibits distinct dynamic and topographic features relative to the brain’s other networks, yet their link to consciousness remains unclear. We review both neural (DMN-based topography and dynamics) and mental (experience of time speed, mental time travel, and self-non-self) findings across diverse nonordinary states of consciousness, including reduced (anesthesia,...
Brain and BehaviorJune 1, 2025Alessandro Agostini, Sara Ventura, Silvia Tempia Valenta et al.
Crohn's disease (CD) is associated with psychological disorders and insecure attachment styles, potentially reflecting the long-lasting disease effect. Although functional magnetic resonance imaging (fMRI) studies revealed differences in CD patients relative to HC, the brain properties underlying the attachment dimensions in CD remain scarcely investigated. We carried out an fMRI study to...
OBJECTIVE This study investigates the impact of basal ganglia intracerebral hemorrhage (ICH) on default mode network (DMN) connectivity and its relationship with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI). METHOD DMN differences between left/right basal ganglia ICH patients and healthy controls were analyzed respectively. Co-altered brain region...
Abstract Background The brain’s default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. However, the genetic basis linking sociability with DMN function remains underexplored. This study aimed to elucidate the shared genetics and causal relationship between sociability and...