Experienced yoga practitioners show long-term decreases in glucose metabolism in the medial temporal cortex, striatum, and brainstem compared to yoga-naive controls, with greater decreases linked to more years of regular practice. A single yoga practice increased metabolism in the cerebellum. No differences were found in brain structure or resting-state connectivity. The findings suggest that regular yoga practice may induce lasting metabolic changes in brain regions involved in memory, emotion, and motor control, but a prospective study is needed to confirm causality.
Using a porcine model and ex vivo human prostate cancer specimens, a hybrid PSMA tracer (99mTc-EuK-(SO3)Cy5-mas3) administered at a microdosing regime enabled fluorescence-guided robot-assisted radical prostatectomy. In pigs, the prostate gland was visualized based on basal PSMA expression, and tracer half-lives in blood and urine were 85 and 390 minutes, respectively, suggesting an interval of over 7 hours between administration and surgery. Ex vivo fluorescence imaging of human prostate cancer specimens correlated with PSMA immunohistochemistry, confirming tumor identification. The findings indicate that intraoperative PSMA-mediated fluorescence imaging with a microdosing approach is feasible and has translational potential.