Current neuroscience research calls into question the binary model of anesthesia as a state of consciousness shifted by unconsciousness, replacing it with an idea of consciousness as a continuum created by interactions between large-scale cortex and subcortical regions.Meanwhile, psychedelic drugs are making a comeback as potential treatments for treatment-resistant depression, post-traumatic...
Why do some moments imprint themselves in memory while others vanish without a trace? This meta-analysis identifies a dissociation in large-scale brain networks during encoding: networks associated with impairing encoding are task-invariant, whereas those supporting it are task-specific. Drawing on 56 functional magnetic resonance imaging (fMRI) studies employing the subsequent memory paradigm,...
BACKGROUND: Recent advancements in psychedelic research have highlighted psilocybin's potential therapeutic benefits for various mental disorders. Understanding its effects on brain function and identifying predictors of individual responses are essential for developing effective treatments. METHODS: This double-blind, randomized, crossover, and placebo-controlled study enrolled 25 healthy...
Kendo is a martial art that embodies the Zen ideal and practices with bamboo swords, it shares similarities with fencing. Mindfulness is a mental state akin to Zen where one can observe sensations, feelings and thoughts as they happen while remaining impartial to them. Using fMRI of the auditory oddball task we investigated network connectivity based on Menon’s triple network theory and...
PURPOSE: Recently, mental health interventions through mobile applications have been increasing. This study sought to explore what changes occurred in psychometric properties and brain functional connectivity (FC) among people who practiced mindfulness meditation through a mobile application. MATERIALS AND METHODS: Subjects underwent mindfulness-based intervention (MBI) for about 24 minutes...
Flow is a deeply immersive state that supports optimal performance, yet its neural basis under conditions of real-world expertise remains poorly understood. Using functional MRI, this study investigated how long-term Chinese calligraphy expertise relates to flow in a culturally meaningful setting. Expert and novice participants performed imagined embodied handwriting of Kai-Shu and Cao-Shu,...
CorticaDecember 15, 2025Gowtham Karim Rajadurai, Cherine Fahim, Sophie Nicole et al.
Contexte La transe cognitive auto‑induite (TCAI) est un état volontaire d’absorption et d’hyperfocalisation attentionnelle, potentiellement utile pour moduler les réponses au trauma et certaines manifestations dissociatives. Pourtant, ses corrélats neurophysiologiques et ses retombées cliniques demeurent peu intégrés aux modèles actuels de psychotraumatologie. Objectifs (i) Synthétiser...
The global demographic shift toward aging populations has intensified the need for innovative therapeutic interventions targeting late-life mental health conditions, notably depression, loneliness, and existential distress. Traditional pharmacological treatments often exhibit limited efficacy and poor tolerability in older patients, primarily due to age-related physiological changes and the...
Abstract Background Evidence suggests that dreaming is subserved by the default mode network (DMN) (Domhoff, 2022. The Neurocognitive Theory of Dreaming ). β‐amyloid plaques and phosphorylated tau ( p ‐tau) protein tangles accumulate and contribute to abnormal functionality in the DMN long before clinical Alzheimer's disease, and similarly early abnormal DMN functionality is shown by...
ABSTRACT This narrative review synthesized the use of psilocybin-assisted therapy as a promising treatment for alleviating death anxiety in terminally ill patients. The insights presented are derived from findings reported in previous studies. Therefore, this review aimed to assess the efficacy, pharmacology, and mechanisms by which psilocybin alters brain function by affecting 5-HT2A receptors...