Alzheimer s & DementiaDecember 1, 2025Danielle Bukovsky, Aron Amaev, Jianmeng Song et al.
Abstract Background Amnestic mild cognitive impairment (aMCI) is characterized by synaptic loss and cognitive decline and is considered a precursor to Alzheimer’s Disease. Currently, there are no effective treatments for aMCI, and available treatments (i.e., cholinesterase inhibitors) do not appear to improve cognitive or functional outcomes. Psychedelics, including psilocybin, have regained...
Abstract Background Evidence suggests that dreaming is subserved by the default mode network (DMN) (Domhoff, 2022. The Neurocognitive Theory of Dreaming ). β‐amyloid plaques and phosphorylated tau ( p ‐tau) protein tangles accumulate and contribute to abnormal functionality in the DMN long before clinical Alzheimer's disease, and similarly early abnormal DMN functionality is shown by...
Alzheimer s & DementiaDecember 1, 2025Leelavathi N. Madhu, Yogish Somayaji, Sanya Kotian et al.
Abstract Background Chronic neuroinflammation plays a significant role in Alzheimer’s disease (AD) pathogenesis associated with a decline in cognitive and mood function. Currently, there are no effective therapies to alleviate the progression of brain dysfunction in AD. Psilocybin, an FDA‐approved drug for treating major depressive disorder, can restrain neuroinflammation and improve...
Abstract Background Recent studies have highlighted the neuroprotective properties of certain mushrooms. Proposing a research hypothesis for a novel field of study into mitigating the neurological and neuropsychological symptoms associated with Alzheimer's disease (AD) and possible cure with natural methods. Psilocybe cubensis and Hericium erinaceus have proven to show therapeutic effects for...
Abstract Background Traditionally associated with recreational and spiritual uses, psychedelics have gained attention in psychotherapy for their therapeutic potential. Functioning as potent 5‐hydroxytryptamine (5HT) agonists, these compounds have demonstrated the ability to enhance neural plasticity by activating serotoninergic and glutamatergic systems. Despite these recognized effects, their...
AbstractBackgroundWe previously reported that increasing participation in Chinese calligraphy handwriting, one of the “Four Arts” traditionally mastered by intellectuals in China and currently widely practiced by older adults in the Chinese community, led to better working memory among individuals with subjective cognitive decline (but without mild or major neurocognitive disorder). Given that...
Case report notions of unexpected memory retrieval in patients with severe dementia near to death are starting to alter the central "irreversible" paradigm of dementia and locate dementia as a problem of memory retrieval, not consolidation. We suggest that the most likely central tenet of this paradoxical memory retrieval is the fluctuation of neuromodulators projecting from the brain stem to...
Abstract Background The primary focus of mindfulness‐based program (MBP) research to date has been on mental health. More recently, attention has turned to putative effects on cognition. An evidence synthesis is required to answer the key question of ‘Do MBPs confer cognitive benefit, and if so, for whom?’ A particularly crucial distinction is whether benefits differ according to individuals’...
Alzheimer s & DementiaMarch 1, 2014Peter J. Snyder, Yen Ying Lim, Rachel Schindler et al.
Abstract: Background: Abnormal β‐amyloid (Aβ) is associated with deleterious changes in central acetylcholinergic tone in the very early stages of Alzheimer's disease (AD), which may be unmasked by a cholinergic antagonist. We aimed to establish an optimal “microdose” of scopolamine for the development of a “cognitive stress test.” Methods: Healthy older adults (n = 26, aged 55–75 years) with...
Alzheimer s & DementiaJuly 1, 2011Lap Ho, Patricia A. Bloom, Joan Griffiths Vega et al.4 citations
Numerous studies have documented that caregiving for a dementia patient may be associated with increased risk of emotional distress, depression, dementia, physical health problems, and death. Other studies suggest that targeting caregivers as the recipients of interventions may greatly improve Alzheimer's care, leading to reduced behavioral symptoms and increased length of time that the...
Alzheimer s & DementiaJuly 1, 2011Márcio Luiz Figueredo Balthazar, Tátila Martins Lopes, Ana Carolina Coan et al.
Dysfunction of brain's Default Mode Network (DMN) has been increasingly described in patients with neurodegenerative diseases, but little is known about DMN's intrinsic functional connectivity (IFC) in Posterior Cortical Dysfunction (PCD) syndrome. We report a 56 year-old woman with PCD syndrome (MMSE = 24, CDR = 0.5) with visuospatial and anxiety complaints, confirmed by neuropsychological...