Journal of Psychopharmacology
April 23, 2019
Matthew B. Wall, Rebecca Pope, Tom P. Freeman et al.
89 citations
BACKGROUND: -tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC. AIMS: We examined the effects of two strains of cannabis and placebo on the human brain's resting-state networks using fMRI. METHODS: Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug...
Frontiers in Human Neuroscience
April 12, 2019
Tracie D. Parkinson, J. Kornelsen, Stephen D. Smith
Mindfulness has been described as an orienting of attention to the present moment, with openness and compassion. Individuals displaying high trait mindfulness exhibit this tendency as a more permanent personality attribute. Given the numerous physical and mental health benefits associated with mindfulness, there is a great interest in understanding the neural substrates of this trait. The...
February 8, 2019
Joshua Eichler-Summers
preprint
Mind-wandering is associated with the simultaneous activation of a network of different brain regions known formally as the default mode network. Forward looking anxious mind-wandering (or worry) occurs when activity in this network is coupled with a biological fear response in the brain. The fear response constrains the con-tent of anxious mind-wandering, with imagined catastrophised scenarios...
Neuroimage
January 15, 2019
Adam Turnbull, Hao-ting Wang, Jonathan W. Schooler et al.
Cognition is dynamic, allowing us the flexibility to shift focus from different aspects of the environment, or between internally- and externally-oriented trains of thought. Although we understand how individuals switch attention across different tasks, the neurocognitive processes that underpin the dynamics of less constrained elements of cognition are less well understood. To explore this...
Biological Psychiatry
2019
Kaustubh Supekar, Weidong Cai, R. Krishnadas et al.
BACKGROUND Schizophrenia is a highly disabling psychiatric disorder characterized by a range of positive "psychosis" symptoms. However, the neurobiology of psychosis and associated systems-level disruptions in the brain remain poorly understood. Here, we test an aberrant saliency model of psychosis, which posits that dysregulated dynamic cross-network interactions among the salience network...
Progress in Brain Research
2019
Antonino Raffone, Laura Marzetti, Cosimo Del Gratta et al.
The rapidly progressing science of meditation has led to insights about the neural correlates of focused attention meditation (FAM), open monitoring meditation (OMM), compassion meditation (CM) and loving kindness meditation (LKM), in terms of states and traits. However, a unified theoretical understanding of the brain mechanisms involved in meditation-related functions, including mindfulness,...
Frontiers in Human Neuroscience
2019
Paul Dennison
1 citation
The "neural correlates of consciousness" (NCC) is a familiar topic in neuroscience, overlapping with research on the brain's "default mode network." Task-based studies of NCC by their nature recruit one part of the cortical network to study another, and are therefore both limited and compromised in what they can reveal about consciousness itself. The form of consciousness explored in such...
Neuroreport
December 5, 2018
Diego B G Rodrigues, Shirley S Lacerda, Joana B Balardin et al.
Among several cognitive advantages, meditation is thought to enhance practitioners' capacity for sustained attention. In the present study, we explored this question by testing meditation practitioners (meditators) and nonpractitioners (nonmeditators) on a task that requires sustained attention, the Stroop Word-Color Task (SWCT), while using functional MRI. Participants were all right-handed...
Pain
December 1, 2018
Fadel Zeidan, Tim V Salomons, Suzan R Farris et al.
Interindividual differences in pain sensitivity vary as a function of interactions between sensory, cognitive-affective, and dispositional factors. Trait mindfulness, characterized as the innate capacity to nonreactively sustain attention to the present moment, is a psychological construct that is associated with lower clinical pain outcomes. Yet, the neural mechanisms supporting dispositional...
Schizophrenia Research
December 1, 2018
Minji Bang, Hae-Jeong Park, Chongwon Pae et al.
23 citations
In the tradition of phenomenology, minimal selfdisturbance has been suggested as a manifestation of the core pathogenesis of schizophrenia; however, the underlying neural mechanism remains unclear. Here, in line with the concept of "cognitive dysmetria," we investigated the cerebro-cerebellar default mode network (DMN) connectivity and its association with pre-reflective minimal selfdisturbance...