Turk psikiyatri dergisi = Turkish journal of psychiatry
2021
U. Kırlı, T. Binbay, K. Alptekin et al.
OBJECTIVE The aim of this study is to evaluate the associations between alcohol-cannabis use and forensic/stressful events with the risk of incident clinical psychosis during follow-up. METHOD A community-based sample (n: 2142) was screened for clinical psychosis (schizophrenia and other psychotic disorders, affective disorders with psychotic features) at baseline and follow-up. Thus, incident...
Traffic injury prevention
2021
Thomas S Burt, Timothy L Brown, Rose Schmitt et al.
Reports indicate that cannabis users will adapt their driving to compensate for the perceived drug effects of cannabis. This analysis examined the relationship between driver perceptions of their state contrasted with objective measures of their performance while operating a motor vehicle. Data was collected from ten subjects in a study examining the effects of cannabis on driving performance....
Medicina
2021
A. J. Kolgashkin, П. Н. Николаев, E. J. Tetenova et al.
1 citation
Cannabis continues to be the most widely used drug worldwide. Recently, there has been two trends in the field: a liberalization of cannabis-related legislation in a number of countries, as well as an increase in the content of the psychoactive component in cannabis plant – tetrahydrocannabinol. The review covers a topic that has been little studied in Russian addiction science – cannabis use...
Psychopharmacology
November 25, 2020
Abril Rangel-Pacheco, Brandon J. Lew, Mikki Schantell et al.
Cognitive processing impairments have been associated with acute cannabis use, but there is mixed evidence regarding the cognitive effects of chronic cannabis use. Several neuroimaging studies have noted selective-attention processing differences in those who chronically use cannabis, but the neural dynamics governing the altered processing is unclear. Twenty-four adults reporting at least...
Scientific Reports
November 23, 2020
A. Zagzoog, Kawthar A. Mohamed, H. J. J. Kim et al.
The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), comparatively little is known about the pharmacology of the less-abundant plant-derived (phyto) cannabinoids. The best-studied transducers of cannabinoid-dependent effects are type 1 and type 2 cannabinoid receptors (CB1R, CB2R). Partial agonism of CB1R...
bioRxiv (Cold Spring Harbor Laboratory)
November 21, 2020
Matthew B. Wall, Tom P. Freeman, Chandni Hindocha et al.
4 citations
preprint
Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are two major constituents of cannabis with contrasting mechanisms of action. THC is the major psychoactive, addiction-promoting, and psychotomimetic compound, while CBD may have somewhat opposite effects. The brain effects of these drugs alone and in combination are poorly understood. In particular the striatum is implicated in the...
Drug and Alcohol Dependence
November 1, 2020
Sarah A. Okey, Madeline H. Meier
Cannabis concentrates have much higher concentrations of THC than marijuana (flower) and are quickly gaining popularity in the United States. One hypothesis is that use of higher-THC cannabis (concentrates) might result in greater intoxication and more severe acute negative effects than lower-THC cannabis (marijuana), but few studies have compared the subjective effects of concentrates and...
Psychological Medicine
October 27, 2020
Marco Colizzi, Nathalie Weltens, David J Lythgoe et al.
8 citations
Abstract Background Cannabis use has been associated with psychosis through exposure to delta-9-tetrahydrocannabinol (Δ9-THC), its key psychoactive ingredient. Although preclinical and human evidence suggests that Δ9-THC acutely modulates glial function and hypothalamic-pituitary-adrenal (HPA) axis activity, whether differential sensitivity to the acute psychotomimetic effects of Δ9-THC is...
European Addiction Research
October 20, 2020
Miriam Wittemann, Jule Brielmaier, M. Rubly et al.
Introduction: Acute and long-term adverse effects of heavy cannabis use (HCU) on neurocognitive function have been suggested, as much as regional changes of brain volume. However, little is known about the relationship between impaired cognition and brain structure in individuals with HCU. Objective: Here, we investigated associations between cognition and cortical thickness (CT) in males with...
Journal of Translational Medicine
October 2, 2020
Lara Sharpe, Justin Sinclair, Andrew Kramer et al.
122 citations
BACKGROUND: -tetrahydrocannabinol (THC) has been associated with an anxiogenic response, while anxiolytic activity has been attributed mainly to cannabidiol (CBD). In animal studies, the effects of THC are highly dose-dependent, and biphasic effects of cannabinoids on anxiety-related responses have been extensively documented. A more precise assessment is required of both the anxiolytic and...