Figshare
September 19, 2026
Cassidy R Loparco, Kayla K Tillett, Matthew E Rossheim et al.
preprint
Amanita muscaria mushrooms, known for their hallucinogenic effects, have grown in popularity and availability. However, use can cause delirium, coma, and death. Moreover, the US Food and Drug Administration (FDA) has stated that Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine) are unapproved additives that do not meet the Generally Recognized as...
Substance Use & Misuse
September 19, 2026
Cassidy R Loparco, Kayla K Tillett, Matthew E Rossheim et al.
Objective: Amanita muscaria mushrooms, known for their hallucinogenic effects, have grown in popularity and availability. However, use can cause delirium, coma, and death. Moreover, the US Food and Drug Administration (FDA) has stated that Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine) are unapproved additives that do not meet the Generally...
Psychology of Addictive Behaviors
November 2023
Jack T. Waddell, Jennifer E. Merrill, Sarah A. Okey et al.
Theoretical models of addictive behavior suggest that subjective effects serve as a mechanism through which substance use disorders develop. However, little is known about the subjective effects of simultaneous alcohol and cannabis use, particularly whether simultaneous use (a) heightens specific subjective effects or (b) is related to unique subjective effects relative to single-substance...
Cannabis and Cannabinoid Research
January 16, 2023
Sarah A. Okey, Jack T. Waddell, Rishika Shah et al.
Background: The legal cannabis landscape has greatly outpaced scientific knowledge. Many popular cannabis claims, such as cultivar (colloquially referred to as strain) classification and terpene content producing different subjective effects, are unsubstantiated. This study examined, for the first time, whether cultivar classification (sativa/indica) and terpene content (caryophyllene,...
Drug and Alcohol Dependence
November 1, 2020
Sarah A. Okey, Madeline H Meier
Cannabis concentrates have much higher concentrations of THC than marijuana (flower) and are quickly gaining popularity in the United States. One hypothesis is that use of higher-THC cannabis (concentrates) might result in greater intoxication and more severe acute negative effects than lower-THC cannabis (marijuana), but few studies have compared the subjective effects of concentrates and...