Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties
Journal of Translational Medicine October 2, 2020 Lara Sharpe, Justin Sinclair, Andrew Kramer et al. 122 citations
BACKGROUND: -tetrahydrocannabinol (THC) has been associated with an anxiogenic response, while anxiolytic activity has been attributed mainly to cannabidiol (CBD). In animal studies, the effects of THC are highly dose-dependent, and biphasic effects of cannabinoids on anxiety-related responses have been extensively documented. A more precise assessment is required of both the anxiolytic and...