Valeria Serra, Federico Brandalise, Vivien Miczán et al.
Abstract Dynamic regulation of midbrain dopamine neuron activity is necessary for diverse processes including motivation, novelty detection, reinforcement learning, and cognitive flexibility. By setting the strength of synaptic inputs to dopaminergic neurons, endocannabinoid signaling is essential for regulating dopaminergic activity. Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main...
Hüseyin Beyköylü, Josi Marschall, Elio Sjak-Shie et al.
preprint
Virtual reality psychedelic experiences (VRPEs) may offer accessible alternatives to substance-induced psychedelic experiences, but their phenomenology and how set and setting factors shape the experience remain underexplored. We conducted a study in a naturalistic festival setting where participants (N = 210) engaged with a 7-minute VRPE while continuous intensity ratings and physiological...
Théo Mouhoud, Timothée Lacombe, Olivier Taieb
preprint
Abstract Background Nutmeg ( Myristica fragrans ) active compounds partially metabolize into amphetamine derivatives with hallucinogenic properties. Acute nutmeg intoxication can induce psychotic states, yet this psychotomimetic potential remains largely unrecognized in clinical practice. We report the first case of nutmeg-induced acute psychosis in an adolescent, highlighting the diagnostic...
Ari Brouwer, Robin Carhart-Harris, Charles L. Raison
preprint
It is a paradox that psychotomimetic drugs can relieve symptoms that increase risk of and cooccur with psychosis, such as attention and motivational deficits (e.g., amphetamines), pain (e.g., cannabis) and symptoms of depression (e.g., psychedelics, dissociatives). We introduce the ideas of psychotomimetic compensation and psychotomimetic sensitization to explain this paradox. Psychotomimetic...
Edward S. Adams
preprint
This Article explores the regulation of the cannabis industry, highlighting its origins, history, and shortcomings. The Article then compares the cannabis and psilocybin industries, arguing against the replication of the cannabis regulatory structure for psilocybin. Instead, this Article will propose tailored regulatory solutions designed to address the unique characteristics of psilocybin and...
Milind Raskar
Soma, the sacred plant of the Rigveda, and its Iranian counterpart Haoma in the Avesta, have long remained shrouded in mystery. While earlier scholarship identified Soma with various candidates such as Amanita muscaria, Ephedra, Cannabis, and Peganum harmala, no consensus has emerged. This study offers a multidisciplinary approach, combining textual analysis, fieldwork in the Kutch region of...
SSRN Electronic Journal
Vincent Joralemon
preprint
MDMA is currently a Schedule I controlled substance, the most restrictive category under the Controlled Substances Act. But Lykos Therapeutics' (formerly MAPS PBC) pending New Drug Application for MDMA-assisted therapy as a treatment for PTSD may force the Drug Enforcement Administration's hand: FDA approval supplies the "accepted medical use" that Schedule I drugs are statutorily denied,...