Journal of Psychopharmacology
July 29, 2023
Natalie Ertl, Will Lawn, Claire Mokrysz et al.
17 citations
BACKGROUND/AIM: Cannabis use is highly prevalent in adolescents; however, little is known about its effects on adolescent brain function. METHOD: = 70, 35 adolescents/35 adults). Pre-registered analyses examined the connectivity of seven major cortical and sub-cortical brain networks (default mode network, executive control network (ECN), salience network, hippocampal network and three striatal...
Journal of Cannabis Research
July 26, 2023
Lee Johnson, Marc Malone, Erik R. Paulson et al.
Background Hemp-derived delta-9 tetrahydrocannabinol (∆^9 THC) products are freely available for sale across much of the USA, but the federal legislation allowing their sale places only minimal requirements on companies. Products must contain no more than 0.3% ∆^9 THC by dry weight, but no limit is placed on overall dosage and there is no requirement that products are tested. However, some...
Cannabis and Cannabinoid Research
July 26, 2023
Valentina Lorenzetti, Eugene McTavish, Samantha J Broyd et al.
Introduction: Cannabis use is associated with brain functional changes in regions implicated in prominent neuroscientific theories of addiction. Emerging evidence suggests that cannabidiol (CBD) is neuroprotective and may reverse structural brain changes associated with prolonged heavy cannabis use. In this study, we examine how an ∼10-week exposure of CBD in cannabis users affected...
Frontiers in Neuroscience
July 18, 2023
Guy Shapira, Ifat Israel-Elgali, Meitar Grad et al.
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3-4 orders of magnitude lower than the standard dose for rodents) exerts distinct, long-term neuroprotection in model mice subjected to acute neurological insults....
Cannabis and Cannabinoid Research
July 13, 2023
Laurel P Gibson, Angela D Bryan
Background: The use of cannabis with various forms of exercise (e.g., running) has received increased media attention in recent years, contradicting the popular stereotype that cannabis is associated with sedentary behavior. Although cross-sectional evidence suggests a positive association between cannabis use and exercise engagement, to date, the acute effects of cannabis on exercise remain...
Journal of Exploratory Research in Pharmacology
July 12, 2023
Marilyn Helen Silva
1 citation
Cannabis sativa contains phytocannabinoids that are psychoactive and neurotoxic (delta-9-tetrahydrocannabinol: Δ9THC) or nonpsychoactive and presumptively neuroprotective (cannabidiol: CBD). Along with rising legalization, availability, and demand, the Δ9THC:CBD ratio also has increased. Cannabis legalization means that use will likely increase in pregnant or breastfeeding women, affecting all...
Journal of dual diagnosis
July 3, 2023
Benedikt Fischer, W. Hall, T. Fidalgo et al.
Abstract Objective: Cannabis use is increasingly normalized; psychosis is a major adverse health outcome. We reviewed evidence on cannabis use-related risk factors for psychosis outcomes at different stages toward recommendations for risk reduction by individuals involved in cannabis use. Methods: We searched primary databases for pertinent literature/data 2016 onward, principally relying on...
Drug and Alcohol Review
July 2023
Jesse Lineham, Elle Wadsworth, David Hammond
Few studies have examined consumer knowledge and communication of tetrahydrocannabinol (THC) content among cannabis consumers, including potential differences by cannabis legislation. The study sought to: (i) examine self-reported knowledge of THC content across 10 cannabis products; (ii) examine self-reported intoxication levels; and (iii) examine association between self-reported THC levels...
Biological Psychiatry Global Open Science
July 2023
Ahmed Hasbi, Bertha K. Madras, Susan R George
Frequent cannabis use is associated with a higher risk of developing cannabis use disorder and other adverse consequences. However, rodent models studying the underlying mechanisms of the reinforcing and withdrawal effects of the primary constituent of cannabis, Δ9-tetrahydrocannabinol (THC), have been limited. This study investigated the effects of daily THC (1 mg/kg, intraperitoneal, 9 days)...
Cureus
July 1, 2023
Martin Leczycki, P. Zaki, Eduardo D. Espiridion
“Moon rock” cannabis is a type of new and highly potent preparation of cannabis, which is made of a strain of cannabis dipped in hash oil and sprinkled with kief crystals, effectively increasing the concentration of δ-9-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, well beyond what is naturally found in the cannabis plant. The use of increasingly potent forms of...