Brazilian Journal of Health Review
September 21, 2023
Ingra Dalcin Pereira, João Ricardo Girotto
1 citation
A esquizofrenia representa um transtorno incapacitante com relação genética e com fatores ambientais. Entre os fatores ambientais está o consumo de substâncias psicoativas como a cannabis. O uso dessa substância tem sido frequentemente associado à geração de episódios de psicose, sintomas psiquiátricos, sendo aventada uma importante relação com a esquizofrenia. OBJETIVO: Avaliar como se dá a...
International Journal of Environmental Research and Public Health
September 18, 2023
Samantha Hurn
This report documents the case of a patient (the author) participating in a clinical trial of medical cannabis (Cannabis sativa L.)-the Sapphire Access Scheme, run by the Sapphire Medical Clinic as part of the UK Medical Cannabis Registry-to explore the impacts of cannabis-based medicinal products (CBMPs) on anxiety. For most of my life, I have experienced often very serious bouts of poor...
Trials
September 9, 2023
Zach Walsh, Ian Mitchell, Kim Crosby et al.
The last few decades have seen increasing interest in the use of cannabis for post-traumatic stress disorder (PTSD). Recent attempts to evaluate the clinical efficacy of cannabis for PTSD were inconclusive and generalizability was limited by undesirable features of the study drug. The present clinical trial evaluated the effects of a commercially available chemovar that was delivered by...
EClinicalMedicine
September 8, 2023
Mathilde Argote, Guillaume Sescousse, Jérôme Brunelin et al.
31 citations
Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important...
Cannabis and Cannabinoid Research
September 2023
Catherine F Moore, Julie A. Marusich, Mehdi Haghdoost et al.
Introduction: Cannabis contains a multitude of phytocannabinoids and terpenes in addition to its main psychoactive constituent, delta-9-tetrahydrocannabinol (D9-THC). It is believed that the combination of minor cannabinoids and terpenes with D9-THC may impact the subjective and physiological effects of D9-THC. In this study, select minor cannabinoids (cannabigerol [CBG], cannabidivarin [CBDV],...
Addictive Behaviors
September 2023
Kat Petrilli, Lindsey A. Hines, Sally Adams et al.
Cannabis potency (concentration of Δ-9-Tetrahydrocannabinol) has been associated with risks of adverse mental health outcomes and addiction but no studies have triangulated evidence from self-report and objective measures of cannabis potency. We hypothesised that users of high potency cannabis would have higher levels of (a) anxiety, (b) depression and (c) psychosis-like symptoms (d) cannabis...
NEJM evidence
September 2023
Philip E Mosley, Lachlan Webb, Anastasia Suraev et al.
BACKGROUND: Tourette syndrome is characterized by chronic motor and vocal tics. There is preliminary evidence of benefit from cannabis products containing Δ9-tetrahydrocannabinol (THC) and that coadministration of cannabidiol (CBD) improves the side-effect profile and safety. METHODS: In this double-blind, crossover trial, participants with severe Tourette syndrome were randomly assigned to a...
Indian Journal of Psychiatry
September 1, 2023
Soumya Jha, Rupa Jha, Wenona Fernandes et al.
1 citation
Context: Cannabis use has been the most commonly used illicit psychoactive substance in India. Increasing use of cannabis has been associated with an increased risk of co-morbid psychotic spectrum disorders with worse outcomes. This risk increases with increased use in a dose-dependent manner. A very complex association exists between cannabis use and mental illness hence it is essential to...
International Journal of Mental Health and Addiction
August 29, 2023
Andrea Escelsior, Alice Trabucco, M. Radicati et al.
Time perception received growing interest in psychiatry for its psychopathological implications. Cannabis use can cause a subjective experience of temporal perception alteration and increases the risk of emergence of mental illnesses such as psychotic and mood disorders. In this framework, we systematically reviewed the findings regarding the clinical, cognitive, and neurobiological correlates...
International Journal of Molecular Sciences
August 22, 2023
Alistair V W Nunn, Geoffrey W Guy, Jimmy D Bell
Before the late 1980s, ideas around how the lipophilic phytocannabinoids might be working involved membranes and bioenergetics as these disciplines were "in vogue". However, as interest in genetics and pharmacology grew, interest in mitochondria (and membranes) waned. The discovery of the cognate receptor for tetrahydrocannabinol (THC) led to the classification of the endocannabinoid system...