Potency and safety analysis of hemp delta-9 products: the hemp vs. cannabis demarcation problem
Lee Johnson, Marc Malone, Erik R. Paulson, Josh M Swider, David C. Marelius, Susan Andersen, Dominic Black
Journal of Cannabis Research July 26, 2023 DOI: 10.1186/s42238-023-00197-6 (opens in new tab)
The journal has published a correction to this paper. Read the correction (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Product testing study (market survey with laboratory analysis) Peer reviewed |
|---|---|
| Sample size | 53 |
| Population | Commercially available hemp-derived delta-9 THC products sold in the USA |
| Topics | Cannabis |
| Key findings | Most products (96.2%) were under the legal delta-9 THC limit, but 66.0% deviated from their labeled dose by more than 10%, and 49% contained THC converted from CBD. Among products providing lab reports, 71.1% did not test for impurities, and only 15.1% performed age verification at checkout. The authors contend these findings raise consumer safety and consent concerns. |
Abstract
Background: Hemp-derived delta-9 tetrahydrocannabinol (∆^9 THC) products are freely available for sale across much of the USA, but the federal legislation allowing their sale places only minimal requirements on companies. Products must contain no more than 0.3% ∆^9 THC by dry weight, but no limit is placed on overall dosage and there is no requirement that products are tested. However, some states—such as Colorado—specifically prohibit products created by “chemically modifying” a natural hemp component.
Methods: Fifty-three ∆^9 THC products were ordered and submitted to InfiniteCAL laboratory for analysis. The lab analysis considered potency, the presence of impurities, and whether the ∆^9 THC present was natural or converted from CBD. The presence of age verification, company-conducted testing, and warning labels was also considered.
Results: While 96.2% of products were under the legal ∆9 THC limit, 66.0% differed from their stated dosage by more than 10%, and although 84.9% provided a lab report to customers, 71.1% of these did not check for impurities. Additionally, 49% of products converted CBD to THC to achieve their levels, and only 15.1% performed age verification at checkout.
Conclusions: Despite some positive findings, the results show that hemp ∆^9 THC companies offer inaccurately labeled products that contain more THC than would be allowed in adult-use states. This raises serious issues around consumer safety, and consent when consuming intoxicating products. Steps to boost accountability for companies must be considered by either the industry or lawmakers if intoxicating hemp products are to remain on the market safely.
Comparable studies
Other cross-sectional and survey studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Cannabis use before age 15 and subsequent executive functioning 104 chronic cannabis users (49 early-onset before age 15, 55 late-onset after age 15)... | 2011 | Observational cross-sectional study | n = 148 |
| Patterns of simultaneous polysubstance use in drug using university students Drug-using university students | 2006 | Cross-sectional survey | n = 149 |
| Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey Online survey respondents | 2020 | Cross-sectional survey | |
| User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study Users of hallucinogenic drugs who completed a web-based questionnaire | 2010 | Cross-sectional survey | n = 600 |
| Illicit Use of LSD or Psilocybin, but not MDMA or Nonpsychedelic Drugs, is Associated with Mystical Experiences in a Dose-Dependent Manner Adults recruited from the MAPS website and newsletter, most reporting use of various... | 2012 | Cross-sectional survey | n = 337 |
Citations in the library
Cites 3
- Review of delta‐8‐tetrahydrocannabinol (Δ8‐THC): Comparative pharmacology with Δ9‐THC British Journal of Pharmacology August 1, 2022
- Delta-8-THC: Delta-9-THC’s nicer younger sibling? Journal of Cannabis Research January 4, 2022
- Cannabis and psychosis/schizophrenia: human studies European Archives of Psychiatry and Clinical Neuroscience July 16, 2009