Cambridge University Press eBooks
May 12, 2023
Edoardo Spinazzola, Marta Di Forti, Robin Murray
The fact that not all cannabis users will develop psychosis suggests that cannabis may exert its causal role only in pre-disposed individuals. However, since the number of people who use cannabis worldwide is so high, those who will eventually develop psychosis, whilst still a minority, represent a large number. The evidence indicates that different patterns of cannabis use have a different...
AIDS and behavior
May 8, 2023
C. Watson, E. Sundermann, J. Helm et al.
Cannabis use is rapidly increasing among older adults in the United States, in part to treat symptoms of common health conditions (e.g., chronic pain, sleep problems). Longitudinal studies of cannabis use and cognitive decline in aging populations living with chronic disease are lacking. We examined different levels of cannabis use and cognitive and everyday function over time among 297 older...
Psychiatry Research
May 8, 2023
Alex Gonzalez Segura, Anna Mané, L. Prohens et al.
5 citations
Cannabis use is highly prevalent in first-episode psychosis (FEP) and plays a critical role in its onset and prognosis, but the genetic underpinnings promoting both conditions are poorly understood. Current treatment strategies for cannabis cessation in FEP are clearly inefficacious. Here, we aimed to characterize the association between cannabis-related polygenic risk scores (PRS) on cannabis...
BMC Psychiatry
May 5, 2023
Stefan Roepke, Nikola Schoofs, Kathlen Priebe et al.
Distressing nightmares are a core symptom of posttraumatic stress disorder (PTSD) and contribute to psychiatric comorbidity, impaired physical health and decreased social functioning. No specific pharmacological treatment for PTSD-related nightmares is yet approved. Preliminary clinical data indicate that cannabinoid agonists can improve nightmares and overall PTSD symptoms in patients with...
Cerebral Cortex
May 4, 2023
Xinying Wang, Hui Zhou, Yuzheng Hu
Negative emotional state has been found to correlate with poor cognitive performance in cannabis-dependent (CD) individuals, but not healthy controls (HCs). To examine the neural substrates underlying such unusual emotion-cognition coupling, we analyzed the behavioral and resting state fMRI data from the Human Connectome Project and found opposite brain-behavior associations in the CD and HC...
Psychological Medicine
May 4, 2023
Giulia Trotta, Victoria Rodriguez, Diego Quattrone et al.
Abstract Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods Data were...
Psychological Medicine
May 2, 2023
Edoardo Spinazzola, Diego Quattrone, Victoria Rodriguez et al.
Abstract Background While cannabis use is a well-established risk factor for psychosis, little is known about any association between reasons for first using cannabis (RFUC) and later patterns of use and risk of psychosis. Methods We used data from 11 sites of the multicentre European Gene-Environment Interaction (EU-GEI) case–control study. 558 first-episode psychosis patients (FEPp) and 567...
Journal of the American Association of Nurse Practitioners
May 1, 2023
Amy L Haycraft
The development of anxiety disorders and post-traumatic stress disorder (PTSD) is complex. Both delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are of potential therapeutic use. Evidence suggests that cannabis has a beneficial effect on neural circuitry involved in fear regulation. In the United States, cannabis is considered either medical or recreational and can contain pure THC or...
Psychopharmacology
May 2023
Briac Halbout, Collin Hutson, Leann Hua et al.
The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs can cause persistent adaptions in the endocannabinoid system and associated neural circuitry. It remains unclear how such treatments affect the way rewards are processed and pursued. We examined if repeated THC exposure (5...
Journal of Studies on Alcohol and Drugs
May 1, 2023
Matthew E Rossheim, Cassidy R Loparco, Doug Henry et al.
41 citations
The 2018 U.S. Federal Agriculture Improvement Act ("Farm Bill") resulted in what some have called a "legal loophole" in cannabis regulation. As different types of cannabis products proliferate, so has the terminology used to attempt to categorize them. This article presents a variety of potential descriptors to encourage dialogue about the language used to classify the multitude of psychoactive...