Psychological Medicine
2024
Simon Kapler, Laura Adery, Gil D Hoftman et al.
Cannabis use is consistently associated with both increased incidence of frank psychotic disorders and acute exacerbations of psychotic symptoms in healthy individuals and people with psychosis spectrum disorders. Although there is uncertainty around causality, cannabis use may be one of a few modifiable risk factors for conversion to psychotic disorders in individuals with Clinical High Risk...
Frontiers in Psychiatry
2024
Xinyi Liang, Maria-Mihaela Avram, Toni Gibbs-Dean et al.
Cannabis users present an important group for investigating putative mechanisms underlying psychosis, as cannabis-use is associated with an increased risk of psychosis. Recent work suggests that alterations in belief-updating under uncertainty underlie psychosis. We therefore compared belief updating under uncertainty between cannabis and non-cannabis users. 49 regular cannabis users and 52...
Frontiers in Pharmacology
2024
Jack M Ognibene, Rajeev I Desai, Praveen P Kulkarni et al.
There are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This raises a concern that chronic use of cannabis high in Δ9-THC may alter the sensitivity to amphetamines. In this exploratory study we hypothesized chronic exposure to Δ9-THC through vaporized cannabis would diminish the central nervous system (CNS)...
PLoS One
2024
Mark J H Lim, Rajan Iyyalol, Joseph W Y Lee et al.
Abnormally widened spatial and temporal binding windows (SBW/TBWs; length of space/time whereby stimuli are considered part of the same percept) are observed in schizophrenia. TBW alterations have been associated with altered sense of agency (hereafter referred to as agency), and an associative relationship between embodiment (body ownership) and agency has been proposed. SBWs/TBWs are...
Case Reports in Psychiatry
2024
Richard C. J. Bradlow, Sophie Wright, Anamaria Szrajbman Vaz da Silva et al.
3 citations
Introduction: There has been a recent significant increase in medical cannabis prescribing in Australia despite weak evidence for its effectiveness in treating the most common indications. Concern has been raised about the potential harms of inappropriate prescription of cannabis; however, there have been no prior published cases of psychosis secondary to medicinal cannabis in Australia. Case...
Journal of Psychoactive Drugs
2024
Daniel J. Kruger, Carlton Cb Bone, Meredith C Meacham et al.
9 citations
There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and users have claimed that THC-Oac produces psychedelic effects; the current study is the first to examine this claim. Researchers developed an online survey for THC-Oac consumers based on previous cannabis and psychedelic use surveys and in consultation with the moderator of...
Schizophrenia Research: Cognition
December 20, 2023
H. Rachid, Zineb Saif, Salma Raoui et al.
Introduction Cannabis use impairs cognitive performance in healthy subjects; several studies have shown improved cognitive outcomes in schizophrenic patients using cannabis. The aim of this study was to evaluate the effects of cannabis use on cognitive function in Moroccan patients with schizophrenia who were cannabis users. Method Two groups were recruited in a Moroccan University Psychiatric...
Experimental and Clinical Psychopharmacology
December 2023
Renée Martin-Willett, Carillon J. Skrzynski, Hollis C Karoly et al.
Highly potent cannabis concentrates are widely available and associated with affective disturbance and cannabis use disorder. Little is known about the effects of concentrated Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and their relationship to long-term affect. We explored how baseline affective symptoms (anxiety and depression) relate to acute (i.e., immediate or short-term)...
Computational biology and chemistry
December 2023
Pukar Khanal, Vishal S Patil, B M Patil et al.
Delta-9-tetrahydrocannabinol, a component of marijuana, interacts with cannabinoid receptors in brain involved in memory, cognition, and emotional control. However, marijuana use and schizophrenia development is a complicated and contentious topic. As a result, more investigation is needed to understand this relationship. Through the functional enrichment analysis, we report the...
Current Psychiatry
December 1, 2023
Joseph M Maes
For some who are predisposed to psychosis, cannabis