Human Psychopharmacology: Clinical and Experimental
September 1, 2025
Renée Martin-Willett, Carillon J. Skrzynski, Angela D Bryan et al.
This study examined the effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) on negative mood and drinking behaviors, and whether those effects were moderated by levels of perceived discrimination among participants who identify with a racial, ethnic, gender, or sexual identity that is underrepresented in research. Participants were either not using cannabis, using cannabis with THC, or...
Frontiers in Behavioral Neuroscience
July 1, 2025
Richard G. Hunter, Annelise Madison, Jonathon K. Lisano et al.
Introduction Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on...
Cannabis and Cannabinoid Research
June 17, 2024
Madeline K Stanger, Harmony O Soffer, Angela D Bryan et al.
1 citation
Introduction: In Colorado, both cannabis and psilocybin are legal and becoming more commonly used. However, there is almost no research detailing the public health concerns regarding negative outcomes (e.g., dependence) of cannabis and psilocybin co-use and motives that may perpetuate these negative outcomes (e.g., coping, boredom). Methods: Using data from a larger observational study on...
Cannabis and Cannabinoid Research
January 22, 2024
L. Bidwell, Renée Martin-Willett, Carillon J. Skrzynski et al.
Objective: Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have varying pharmacological actions with differential effects on acute and extended affective states, incuding anxiety. We aimed to study these effects on anxiety in legal market forms of cannabis. Method: This study makes use of a nonequivalent control group quasiexperimental design. Forty-two participants with anxiety symptions...
Experimental and Clinical Psychopharmacology
December 2023
Renée Martin-Willett, Carillon J. Skrzynski, Hollis C Karoly et al.
Highly potent cannabis concentrates are widely available and associated with affective disturbance and cannabis use disorder. Little is known about the effects of concentrated Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and their relationship to long-term affect. We explored how baseline affective symptoms (anxiety and depression) relate to acute (i.e., immediate or short-term)...
Psychology of Addictive Behaviors
May 18, 2023
Carillon J. Skrzynski, Angela D Bryan, Kent E. Hutchison
Objective: This study compared two mechanisms by which mindfulness may reduce hazardous drinking: effortful control and craving, "top-down" and "bottom-up" processes, respectively. These relationships were compared in a secondary analysis of a randomized controlled trial of mindfulness-based relapse prevention (MBRP) versus relapse prevention (RP) treatments to explore if they differed based on...
Frontiers in Aging Neuroscience
February 10, 2022
K. Watson, Angela D Bryan, R. Thayer et al.
Several lines of evidence suggest that older adults (aged 65+) sharply increased their cannabis use over the last decade, highlighting a need to understand the effects of cannabis in this age group. Pre-clinical models suggest that cannabinoids affect the brain and cognition in an age-dependent fashion, having generally beneficial effects on older animals and deleterious effects on younger...