In silico characterization of the psilocybin biosynthesis pathway.
Computational biology and chemistry June 1, 2023 William Irvine, Marshall Tyler, Rupika Delgoda 11 citations
Nearly all mushrooms of the Psilocybe genus contain the natural product psilocybin, which is a psychoactive alkaloid derived from l-tryptophan. Considering their use in ancient times, as well as their psychedelic properties, these mushrooms have re-emerged with psychotherapeutic potential for treating depression, which has triggered increased pharmaceutical interest. However, the psilocybin...